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Research ArticleImaging

Dose Optimization in 18F-FDG PET Based on Noise-Equivalent Count Rate Measurement and Image Quality Assessment

Nivedita Rana, Manpreet Kaur, Harmandeep Singh and Bhagwant Rai Mittal
Journal of Nuclear Medicine Technology March 2021, 49 (1) 49-53; DOI: https://doi.org/10.2967/jnmt.120.250282
Nivedita Rana
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
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Manpreet Kaur
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
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Harmandeep Singh
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
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Bhagwant Rai Mittal
Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
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Abstract

The present study aimed to optimize the injected dose of 18F-FDG in whole-body PET/CT scans and assess its effect on noise-equivalent count rate (NECR) and visual image quality (IQ). Methods: Patients scheduled to undergo 18F-FDG PET/CT were prospectively recruited in the study from January to December 2019, regardless of the indication or underlying disease. Patients were divided into 4 groups and injected with different amounts of 18F-FDG radioactivity per kilogram of body weight (1.85, 3.7, 5.5, and 7.4 MBq/kg). All patients underwent 18F-FDG PET/CT studies, and NECRlocal was calculated by noting the trues rate, total prompts, and randoms rate for each bed position. Whole-body NECRglobal was calculated as the average NECR for all bed positions. IQ was qualitatively assessed for each bed position (IQlocal) and for whole-body PET (IQglobal) by 2 readers using 5-point scores based on prevalence of noise, contrast, and lesion detectability. NECR and IQ were compared among all 4 activity groups. Patients were also subdivided into 4 body-mass-index groups (group I, 15–20 kg/m2; group II, 20.1–25 kg/m2; group III, 25.1–30 kg/m2; and group IV, 30.1–35 kg/m2) for comparison. A P value of less than 0.05 was considered significant. Results: In total, 109 patients underwent 18F-FDG PET/CT studies after injection of different amounts of 18F-FDG radioactivity and a mean uptake time of 62.32 min. The mean NECRglobal and IQglobal for each group were significantly different from other groups (P < 0.05), with NECR and IQ being higher in high-activity groups than in low-activity groups. The overall IQ was acceptable in all patients, even in the lowest-activity group (1.84 MBq/kg). The mean NECRglobal and IQglobal were significantly different in all 4 body-mass-index groups (P < 0.05), except between groups II and III (P > 0.05). NECRlocal and IQlocal correlated moderately (r = 0.64). Conclusion: Optimization of injected 18F-FDG radioactivity from 7.4 MBq/kg (200 μCi/kg) to 1.85 MBq/kg (50 μCi/kg) resulted in acceptable IQ, despite a reduction in NECR.

  • NECR
  • image quality
  • FDG PET
  • dose optimization

Footnotes

  • ↵* Contributed equally to this work.

  • Published online Sep. 4, 2020.

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Journal of Nuclear Medicine Technology: 49 (1)
Journal of Nuclear Medicine Technology
Vol. 49, Issue 1
March 1, 2021
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Dose Optimization in 18F-FDG PET Based on Noise-Equivalent Count Rate Measurement and Image Quality Assessment
Nivedita Rana, Manpreet Kaur, Harmandeep Singh, Bhagwant Rai Mittal
Journal of Nuclear Medicine Technology Mar 2021, 49 (1) 49-53; DOI: 10.2967/jnmt.120.250282

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Dose Optimization in 18F-FDG PET Based on Noise-Equivalent Count Rate Measurement and Image Quality Assessment
Nivedita Rana, Manpreet Kaur, Harmandeep Singh, Bhagwant Rai Mittal
Journal of Nuclear Medicine Technology Mar 2021, 49 (1) 49-53; DOI: 10.2967/jnmt.120.250282
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Keywords

  • NECR
  • image quality
  • FDG PET
  • dose optimization
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