Topical Sensor for the Assessment of PET Dose Administration: Metric Performance with an Autoinjector

Annotated abnormal time–activity curve (with injection curves in black and reference curves in gray) indicating dose extravasation. Panel A highlights AUC for injection sensor (gray region) for aUCR10 on patient with venous retention, whereas panel B highlights AUC (gray region) for reference sensor. aUCR10 is calculated as ratio of AUC from A to AUC from B. Panel C highlights AUC for injection sensor (gray region) for aUCR1 in patient with extravasation of dose, whereas panel D highlights AUC (gray region) for reference sensor. aUCR1 is calculated as ratio of AUC from C to AUC from D. Color version of this figure, showing gray curves as red, is available as supplemental file at http://tech.snmjournals.org. AUC = area under the curve.

Annotated time–activity curves (with injection curve in black and reference curve in gray) for normal dose administration (A), normal administration with autoinjector multiple peaks and wider bolus (B), venous retention with resolution (C), and extravasation without resolution (D). Each time–activity curve is annotated with Lucerno Dynamics metrics automatically generated for monitored injections. Color version of this figure, showing gray curves as red, is available as supplemental file at http://tech.snmjournals.org.