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Journal of Nuclear Medicine Technology

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Review ArticleTeaching Case Studies

Combined 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy and Platinum-Based Chemotherapy in Recurrent, Metastatic Sinonasal Neuroendocrine Carcinoma: A Promising Therapeutic Option

Aadil Adnan and Sandip Basu
Journal of Nuclear Medicine Technology September 2020, 48 (3) 292-294; DOI: https://doi.org/10.2967/jnmt.119.237354
Aadil Adnan
Radiation Medicine Centre, Bhabha Atomic Research Centre, and Homi Bhabha National Institute, Mumbai, India
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Sandip Basu
Radiation Medicine Centre, Bhabha Atomic Research Centre, and Homi Bhabha National Institute, Mumbai, India
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Abstract

Sinonasal neuroendocrine carcinomas (SNCs), in contrast to neuroendocrine carcinomas at other sites, are notorious for their recurrent and locally aggressive nature. The clinical concern is primarily due to their complex anatomy and close proximity to vital structures, compounded by lack of proper understanding of pathogenesis, no definitive classification or staging system, and no established treatment guidelines. We present the promise of combined treatment with 177Lu-DOTATATE–based peptide receptor radionuclide therapy (PRRT) and platinum-based chemotherapy in a patient with high-grade, recurrent, and metastatic SNC (that demonstrated high uptake on both 68Ga-DOTATATE and 18F-FDG PET/CT), which showed a significant partial response. The case report highlights the feasibility and effectiveness of applying a combined protocol of 177Lu-DOTATATE and platinum-based chemotherapy in the management of high-grade, recurrent, metastatic SNC.

  • sinonasal neuroendocrine carcinoma
  • 68Ga-DOTATATE PET/CT
  • 18F-FDG PET/CT
  • 177Lu-DOTATATE
  • peptide receptor radionuclide therapy
  • dual-tracer PET/CT

Footnotes

  • Published online May 1, 2020.

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Journal of Nuclear Medicine Technology: 48 (3)
Journal of Nuclear Medicine Technology
Vol. 48, Issue 3
September 1, 2020
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Combined 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy and Platinum-Based Chemotherapy in Recurrent, Metastatic Sinonasal Neuroendocrine Carcinoma: A Promising Therapeutic Option
Aadil Adnan, Sandip Basu
Journal of Nuclear Medicine Technology Sep 2020, 48 (3) 292-294; DOI: 10.2967/jnmt.119.237354

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Combined 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy and Platinum-Based Chemotherapy in Recurrent, Metastatic Sinonasal Neuroendocrine Carcinoma: A Promising Therapeutic Option
Aadil Adnan, Sandip Basu
Journal of Nuclear Medicine Technology Sep 2020, 48 (3) 292-294; DOI: 10.2967/jnmt.119.237354
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Keywords

  • Sinonasal Neuroendocrine carcinoma
  • 68Ga-DOTATATE PET/CT
  • 18F-FDG PET/CT
  • 177Lu-DOTATATE
  • Peptide Receptor Radionuclide Therapy
  • dual-tracer PET/CT
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