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Journal of Nuclear Medicine Technology

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Review ArticleContinuing Education

DaTQUANT: The Future of Diagnosing Parkinson Disease

Jacquelyn E. Brogley
Journal of Nuclear Medicine Technology March 2019, 47 (1) 21-26; DOI: https://doi.org/10.2967/jnmt.118.222349
Jacquelyn E. Brogley
Gateway Community College, Nuclear Medicine Technology Program, Phoenix, Arizona
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  • FIGURE 1.
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    FIGURE 1.

    (A) Control sample of healthy brain tissue of substantia nigra. Darkened areas (arrow demonstrating portion of darkened outline) show pigmented neuromelanin portions of substantia nigra pars compacta. (B) Positive Parkinson disease tissue sample. Lightened areas demonstrate lack of neuromelanin. (Reprinted with permission of the Tissue User Note, Banner Sun Health Research Institute.)

  • FIGURE 2.
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    FIGURE 2.

    Dopamine transporter synaptic cleft. Stars represent where 123I-ioflupane binds to transporters. (This image was originally published in (9).)

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    FIGURE 3.

    (A) DaT scan images visualizing “semicolon sign.” (B) Forward head-tilt artifact, which falsely represents caudate nuclei separate from putamen. False-positive artifact. (This image was originally published in (11).)

  • FIGURE 4.
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    FIGURE 4.

    Sample save screen of the DaTQUANT (GE 2018) processing: white VOI placement in slices of images; normals database on top right, with red dots representing individual case results against range of normal database cases. Other calculated data at bottom of image. (This image was originally published in (12).)

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Journal of Nuclear Medicine Technology: 47 (1)
Journal of Nuclear Medicine Technology
Vol. 47, Issue 1
March 1, 2019
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DaTQUANT: The Future of Diagnosing Parkinson Disease
Jacquelyn E. Brogley
Journal of Nuclear Medicine Technology Mar 2019, 47 (1) 21-26; DOI: 10.2967/jnmt.118.222349

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DaTQUANT: The Future of Diagnosing Parkinson Disease
Jacquelyn E. Brogley
Journal of Nuclear Medicine Technology Mar 2019, 47 (1) 21-26; DOI: 10.2967/jnmt.118.222349
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Jump to section

  • Article
    • Abstract
    • PARKINSON DISEASE
    • CURRENT DIAGNOSTIC PRACTICES
    • 123I-IOFLUPANE MECHANISM OF ACTION
    • DAT PROTOCOL
    • DATQUANT
    • CONCLUSION
    • DISCLOSURE
    • Acknowledgments
    • Footnotes
    • REFERENCES
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  • Info & Metrics
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  • PET/CT Case Series: Unmasking the Mystery of Cardiac Sarcoidosis
  • Delivery Methods of Radiopharmaceuticals: Exploring Global Strategies to Minimize Occupational Radiation Exposure
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Keywords

  • Parkinson’s disease
  • 123I Ioflupane
  • dopamine transporter
  • DaTQUANT®
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