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Review ArticleTeaching Case Studies

False-Positive Findings on Dopamine Transporter SPECT Due to Therapeutic Dextroamphetamine and Amphetamine

Joseph A. Frankl, Sudeshna Bose and Phillip H. Kuo
Journal of Nuclear Medicine Technology June 2018, 46 (2) 149-150; DOI: https://doi.org/10.2967/jnmt.117.201558
Joseph A. Frankl
1College of Medicine, University of Arizona, Tucson, Arizona
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Sudeshna Bose
2Department of Neurology, University of Arizona, Tucson, Arizona
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Phillip H. Kuo
3Department of Medical Imaging, University of Arizona, Tucson, Arizona;
4Departments of Medicine and Biomedical Engineering, University of Arizona, Tucson, Arizona
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Abstract

Dopamine transporter SPECT is an accurate adjunct to clinical evaluation for Parkinson disease when the diagnosis is difficult. Dopaminergic medications may significantly affect dopamine transporter availability and, thus, uptake of dopamine transporter tracers. A patient had a false-positive dopamine transporter SPECT result while she was taking dextroamphetamine and amphetamine for attention-deficit hyperactivity disorder. The SPECT findings normalized after amphetamine therapy was withheld. An accurate medication history combined with knowledge of drugs that interfere with dopamine transporter imaging is critical to ensure accuracy.

  • dopamine transporter
  • single-photon positron emission tomography
  • ioflupane
  • Parkinson disease
  • amphetamine

Footnotes

  • Published online Dec. 22, 2017.

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Journal of Nuclear Medicine Technology: 46 (2)
Journal of Nuclear Medicine Technology
Vol. 46, Issue 2
June 1, 2018
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False-Positive Findings on Dopamine Transporter SPECT Due to Therapeutic Dextroamphetamine and Amphetamine
Joseph A. Frankl, Sudeshna Bose, Phillip H. Kuo
Journal of Nuclear Medicine Technology Jun 2018, 46 (2) 149-150; DOI: 10.2967/jnmt.117.201558

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False-Positive Findings on Dopamine Transporter SPECT Due to Therapeutic Dextroamphetamine and Amphetamine
Joseph A. Frankl, Sudeshna Bose, Phillip H. Kuo
Journal of Nuclear Medicine Technology Jun 2018, 46 (2) 149-150; DOI: 10.2967/jnmt.117.201558
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Keywords

  • dopamine transporter
  • single-photon positron emission tomography
  • ioflupane
  • Parkinson disease
  • amphetamine
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