Research ArticleImaging

In Vitro PET Imaging of a Miniature Ventricular Assist Device

Michael S. Gossman, Joel D. Graham, Stephen Depot, Huaiyu Zheng, Junling Li, Chin K. Ng and Daniel Tamez
Journal of Nuclear Medicine Technology September 2016, 44 (3) 190-194; DOI: https://doi.org/10.2967/jnmt.116.175885

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    MVAD® surgically attached to heart. (A color version of each of the 6 figures is available as a supplemental file at http://tech.snmjournals.org.)

  • FIGURE 2.
    FIGURE 2.

    Experimental setup: microPET R4 scanner (A), 1.2-L in vitro flow loop with lead bricks shielding loop reservoir (B), MVAD® pump (C), controller connected to MVAD® pump through driveshaft (D), and custom data acquisition system used to capture pump operational parameters (E).

  • FIGURE 3.
    FIGURE 3.

    Real-time pump parameters: speed, power consumption, and flow rate with 18F-NaF and 18F-FDG. The 3 indicated regions are baseline pump operation (A), introduction and circulation of radiotracer (B), and PET imaging (C).

  • FIGURE 4.
    FIGURE 4.

    Cross-sectional PET images of MVAD® pump during circulation of 18F-NaF (A) and 18F-FDG (C) and after loops were drained to determine the amount of residual 18F-NaF (B) and 18F-FDG (D).

  • FIGURE 5.
    FIGURE 5.

    Cross-sectional PET images of MVAD® pump during circulation of 18F-NaF (A) and 18F-FDG (C). Three-dimensional reconstruction of PET images obtained during circulation of 18F-NaF (B) and 18F-FDG (D).

  • FIGURE 6.
    FIGURE 6.

    (A) MVAD® pump with outflow graft connected to loop. (B) Three-dimensional reconstruction of PET image of circulating radiotracer. Image is obscured in region of pump where impeller is spinning at 14,000 rpm. (C) MVAD® pump showing location of suspended spinning impeller.

Tables

  • TABLE 1

    Pump Parameters for 18F-NaF and 18F-FDG at Baseline and During Radiotracer Circulation

    BaselineDuring circulation
    RadiotracerPower consumption (W)Flow rate (L/min)Speed (rpm)Power consumption (W)Flow rate (L/min)Speed (rpm)
    18F-NaF5.39 ± 0.026.16 ± 0.0014,999 ± 35.37 ± 0.026.16 ± 0.0014,999 ± 3
    18F-FDG5.19 ± 0.026.16 ± 0.0014,999 ± 35.19 ± 0.026.16 ± 0.0014,999 ± 3
  • TABLE 2

    Total Radioactivity During and After Radiotracer Circulation

    DuringAfter
    RadiotracerMean ± SDMaximumMean ± SDMaximumRetention
    18F-NaF587.1 ± 772.93,184.91.8 ± 5.1101.00.31%
    18F-FDG627.6 ± 802.33,122.23.8 ± 7.993.10.61%

    • Data are nCi/mL (1 nCi = 37 Bq).

Back to top

In this issue

Print
Download PDF
Article Alerts
Email Article
Citation Tools
Bookmark this article

Jump to section

Keywords