Review ArticleContinuing Education

99mTc-Tilmanocept: A Novel Molecular Agent for Lymphatic Mapping and Sentinel Lymph Node Localization

Devaki Shilpa Surasi, Janis O’Malley and Pradeep Bhambhvani
Journal of Nuclear Medicine Technology June 2015, 43 (2) 87-91; DOI: https://doi.org/10.2967/jnmt.115.155960

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Molecular structure of 99mTc-tilmanocept. It is composed of a dextran backbone to which multiple units of mannose and DTPA are attached. DTPA units serve as attachment sites for radioactive labeling with 99mTc. Mannose units provide a molecular mechanism by which 99mTc-tilmanocept binds to CD206 receptor specific to reticuloendothelial cells.

  • FIGURE 2.
    FIGURE 2.

    Squamous cell carcinoma in floor of mouth. 99mTc-tilmanocept was injected at tumor site, and anterior cervical nodes were visualized bilaterally. ANT = anterior; LAT = lateral.

  • FIGURE 3.
    FIGURE 3.

    Cancer in right breast. After periareolar intradermal injection of 99mTc-tilmanocept in right upper outer quadrant, sentinel node was identified in right axilla. ANT = anterior; LAT = lateral.

  • FIGURE 4.
    FIGURE 4.

    Melanoma in right arm. After intradermal injection of 99mTc-tilmanocept around lesion, sentinel node was identified in right axilla.

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