Article Figures & Data
Figures
- FIGURE 1.
Calculation of heart-to-mediastinum count ratio of 123I-MIBG. Region of interest (ROI) is drawn around left ventricle and in mediastinum. Mediastinal position of ROI is standardized in relation to lung apex, lower boundary of upper mediastinum, and mediastinal midline. Same ROIs are applied for early 15-min postinjection and late 4-h postinjection images, to calculate 4-h washout rates.
where H is decay-corrected average counts of heart ROI, and M is decay-corrected average counts of mediastinum ROI.
Tables
Effect Agent Myocardial depression Anthracyclines, mitoxantrone, high-dose cyclophosphamide, trastuzumab, ifosfamide, all-trans retinoic acid Ischemia 5-fluorouracil, cisplatin, capecitabine, interleukin-2 Hypotension Etoposide, paclitaxel, alemtuzumab, cetuximab, rituximab, interleukin-2, denileukin, interferon-α, all-trans retinoic acid, homoharringtonine Hypertension Bevacizumab, cisplatin Other Busulfan (cardiac tamponade, endomyocardial fibrosis) Cyclophosphamide (hemorrhagic myocarditis) Paclitaxel, thalidomide (bradyarrhythmias) Arsenic trioxide (QT prolongation or torsades de pointes) Technique Tracer Mechanical (pump) function 99mTc MUGA (radionuclide ventriculography or equilibrium radionuclide angiocardiography) 99mTc gated blood-pool SPECT Neuronal imaging 123I-MIBG See Table 3 for neuronal imaging PET tracers Imaging necrosis/cell death 111In-antimyosin Imaging cell death/apoptosis 99mTc-annexin V Fatty acid use 123I-BMIPP 123I-paraphenyl pentadecanoic acid Therapeutic target imaging 111In-trastuzumab Tracer Action Presynaptic tracers Visualize inhibition of further neurotransmission True catecholamines Behave identically to endogenous neurotransmitters 18F-6-fluorodopamine 11C-epinephrine Catecholamine analogs False neurotransmitters 11C-meta-hydroxyephedrine (HED) 11C-phenylephrine 18F-6-fluorometaraminol Postsynaptic tracers Visualize transmission of sympathetic signal to target tissue 11C-CGP12177 11C-CGP12388 11C-GB67
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- Article
- Abstract
- POTENTIAL MECHANISMS OF CARDIOTOXICITY
- ROLE OF SURVEILLANCE AND EARLY DETECTION OF CARDIOTOXICITY
- NONINVASIVE IMAGING OF CARDIOTOXICITY
- 99MTC MUGA
- 99MTC GATED BLOOD-POOL SPECT
- 123I-LABELED MIBG SCINTIGRAPHY
- CARDIAC SYMPATHETIC NEURONAL IMAGING USING PET
- 111IN-ANTIMYOSIN AND 99MTC-LABELED ANNEXIN V
- FATTY ACID USE
- 111IN-TRASTUZUMAB
- SUMMARY AND FUTURE PERSPECTIVES
- Footnotes
- REFERENCES
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