Does the Preparation and Utilization of 99mTc-Sulfur Colloid Affect the Outcomes of Breast Lymphoscintigraphy?

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FIGURE 1.
Distribution of sentinel nodes by group.
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FIGURE 2.
Distribution of sentinel nodes by unit dose.

TABLE 1

Heating Method and Amount of Radioactivity for Each Group

		Amount of activity added to bulk vial of sulfur colloid
Group	Heating method used to prepare bulk vial of sulfur colloid	MBq	mCi
A	Water bath	2,960 ± 10%	80 ± 10%
B	Dry heat block	2,960 ± 10%	80 ± 10%
C	Water bath	6,660 ± 10%	180 ± 10%

TABLE 4

Multivariable Regression for Number of SLNs Visualized for Each Coefficient

Coefficient	Effect	SE	Lower 95% limit	Upper 95% limit	P
Baseline	1.05	0.11	0.83	1.27	<0.0001
Unit dose	0.51	0.083	0.35	0.67	<0.0001
Heating method	−0.026	0.11	−0.24	0.19	0.82
Time difference	−0.04	0.03	−0.1	0.02	0.15
Location in breast tissue for ^99mTc-sulfur colloid administration
IMZ-LIQ	−0.083	0.12	−0.32	0.15	0.48
IMZ-LMZ	0.16	0.12	−0.08	0.4	0.19
IMZ-LOQ	−0.046	0.1	−0.24	0.15	0.65
IMZ-OMZ	−0.16	0.091	−0.34	0.02	0.085
IMZ-UIQ	−0.13	0.091	−0.31	0.05	0.16
IMZ-UMZ	−0.15	0.091	−0.33	0.03	0.11
IMZ-UOQ	−0.25	0.083	−0.41	−0.09	0.003
Unit dose: heating method	−0.26	0.12	−0.5	−0.02	0.068

IMZ = inner mid zone; LIQ = lower inner quadrant; LMZ = lower mid zone; LOQ = lower outer quadrant; OMZ = outer mid zone; UIQ = upper inner quadrant; UMZ = upper mid zone; UOQ = upper outer quadrant.

TABLE 5

Multivariable Regression for Number of Radioactive SLNs Removed for Each Coefficient

Coefficient	Effect	SE	Lower 95% limit	Upper 95% limit	P
Baseline	1.06	0.097	0.87	1.24	0
Unit dose	0.13	0.072	−0.01	0.27	0.069
Heating method	−0.077	0.096	−0.26	0.11	0.42
Time difference	−0.02	0.02	−0.07	0.03	0.38
Location in breast tissue for ^99mTc-sulfur colloid administration
IMZ-LIQ	−0.042	0.1	−0.24	0.16	0.68
IMZ-LMZ	0.2	0.1	0	0.41	0.049
IMZ-LOQ	0.019	0.089	−0.16	0.19	0.83
IMZ-OMZ	0.032	0.079	−0.12	0.19	0.69
IMZ-UIQ	−0.022	0.079	−0.18	0.13	0.78
IMZ-UMZ	0.013	0.078	−0.14	0.17	0.87
IMZ-UOQ	−0.023	0.072	−0.16	0.12	0.75
Unit dose: heating method	−0.1	0.1	−0.3	0.1	0.31

IMZ = inner mid zone; LIQ = lower inner quadrant; LMZ = lower mid zone; LOQ = lower outer quadrant; OMZ = outer mid zone; UIQ = upper inner quadrant; UMZ = upper mid zone; UOQ = upper outer quadrant.

TABLE 6

Multivariable Regression for Number of Lymph Nodes Removed for Each Coefficient

Coefficient	Effect	SE	Lower 95% limit	Upper 95% limit	P
Baseline	1.03	0.095	0.84	1.22	<0.0001
Unit dose	0.17	0.07	0.03	0.31	0.013
Heating method	−0.003	0.094	−0.19	0.18	0.98
Time difference	−0.01	0.02	−0.05	0.03	0.76
Location in breast tissue for ^99mTc-sulfur colloid administration
IMZ-LIQ	−0.038	0.099	−0.23	0.16	0.71
IMZ-LMZ	0.25	0.1	0.05	0.45	0.013
IMZ-LOQ	0.035	0.088	−0.14	0.21	0.69
IMZ-OMZ	0.063	0.078	−0.09	0.22	0.42
IMZ-UIQ	−0.0004	0.078	−0.15	0.15	1
IMZ-UMZ	0.044	0.077	−0.11	0.19	0.57
IMZ-UOQ	0.026	0.071	−0.11	0.17	0.71
Unit dose: heating method	−0.15	0.1	−0.35	0.05	0.13

IMZ = inner mid zone; LIQ = lower inner quadrant; LMZ = lower mid zone; LOQ = lower outer quadrant; OMZ = outer mid zone; UIQ = upper inner quadrant; UMZ = upper mid zone; UOQ = upper outer quadrant.