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Research ArticleRADIOPHARMACY

Evaluation of Compatibility and Stability of Filtered 99mTc-Sulfur Colloid When Combined with Fluorescent Indocyanine Green Dye

Karissa M. Hegseth, Amy M. Warren, Joseph C. Hung and Elton A. Mosman
Journal of Nuclear Medicine Technology September 2012, 40 (3) 194-197; DOI: https://doi.org/10.2967/jnmt.111.097584
Karissa M. Hegseth
Division of Nuclear Medicine, Mayo Clinic, Rochester, Minnesota
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Amy M. Warren
Division of Nuclear Medicine, Mayo Clinic, Rochester, Minnesota
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Joseph C. Hung
Division of Nuclear Medicine, Mayo Clinic, Rochester, Minnesota
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Elton A. Mosman
Division of Nuclear Medicine, Mayo Clinic, Rochester, Minnesota
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  • FIGURE 1.
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    FIGURE 1.

    (A) Filtered 99mTc-sulfur colloid particles when mixed with green dye at 0 h after preparation. (B) Filtered 99mTc-sulfur colloid particles when mixed with green dye at 2 h after preparation.

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    FIGURE 2.

    (A) 99mTc-sulfur colloid particles without green dye. (B) Filtered 99mTc-sulfur colloid particles without green dye. (C) Filtered 99mTc-sulfur colloid with green dye.

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    TABLE 1

    Evaluation of RCP

    TrialnAverage RCP (%) at 0 hAverage RCP (%) at 1 hAverage RCP (%) at 2 h
    1396.1 ± 0.197.5 ± 0.199.0 ± 0.1
    2298.9 ± 0.095.4 ± 0.094.1 ± 0.0
    3399.6 ± 0.197.9 ± 0.198.1 ± 0.1
    4396.5 ± 0.099.1 ± 0.098.5 ± 0.0
    5398.9 ± 0.098.7 ± 0.097.5 ± 0.0
    6394.5 ± 0.196.6 ± 0.198.1 ± 0.1
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    TABLE 2

    Evaluation of pH

    TrialnAverage pH at 0 hAverage pH at 1 hAverage pH at 2 h
    135.07 ± 3.435.18 ± 2.445.18 ± 0.13
    225.61 ± 0.025.78 ± 2.685.85 ± 0.88
    335.58 ± 0.075.77 ± 0.345.47 ± 0.94
    435.30 ± 2.095.38 ± 0.095.59 ± 0.16
    535.58 ± 0.445.87 ± 0.605.77 ± 2.42
    635.62 ± 1.985.84 ± 1.935.88 ± 1.11
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    TABLE 3

    Evaluation of Particle Size

    SamplenAverage particle size (nm)Minimum particle size (nm)Maximum particle size (nm)
    Unfiltered 99mTc-sulfur colloid21253 ± 19231857
    Filtered 99mTc-sulfur colloid4171 ± 4119167
    Mixture of filtered 99mTc-sulfur colloid and green dye at 0 h36553 ± 309156
    Mixture of filtered 99mTc-sulfur colloid and green dye at 2 h30360 ± 3512193
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Journal of Nuclear Medicine Technology: 40 (3)
Journal of Nuclear Medicine Technology
Vol. 40, Issue 3
September 1, 2012
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Evaluation of Compatibility and Stability of Filtered 99mTc-Sulfur Colloid When Combined with Fluorescent Indocyanine Green Dye
Karissa M. Hegseth, Amy M. Warren, Joseph C. Hung, Elton A. Mosman
Journal of Nuclear Medicine Technology Sep 2012, 40 (3) 194-197; DOI: 10.2967/jnmt.111.097584

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Evaluation of Compatibility and Stability of Filtered 99mTc-Sulfur Colloid When Combined with Fluorescent Indocyanine Green Dye
Karissa M. Hegseth, Amy M. Warren, Joseph C. Hung, Elton A. Mosman
Journal of Nuclear Medicine Technology Sep 2012, 40 (3) 194-197; DOI: 10.2967/jnmt.111.097584
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