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Research ArticleIMAGING

Semiautomatic Region-of-Interest Validation at the Femur in 18F-Fluoride PET/CT

Tanuj Puri, Glen M. Blake, Kathleen M. Curran, Hamish Carr, Amelia E.B. Moore, Niall Colgan, Martin J. O’Connell, Paul K. Marsden, Ignac Fogelman and Michelle L. Frost
Journal of Nuclear Medicine Technology September 2012, 40 (3) 168-174; DOI: https://doi.org/10.2967/jnmt.111.100107
Tanuj Puri
1PET Imaging Centre, Imaging Sciences and Biomedical Engineering, St. Thomas’ Hospital, King’s College London, London, United Kingdom
2School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
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Glen M. Blake
3Osteoporosis Screening and Research Unit, Imaging Sciences and Biomedical Engineering, Guy’s Hospital, King’s College London, London, United Kingdom
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Kathleen M. Curran
2School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
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Hamish Carr
4University of Leeds, Leeds, United Kingdom
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Amelia E.B. Moore
3Osteoporosis Screening and Research Unit, Imaging Sciences and Biomedical Engineering, Guy’s Hospital, King’s College London, London, United Kingdom
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Niall Colgan
2School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland
5College of Medicine, Swansea University, Wales, United Kingdom; and
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Martin J. O’Connell
6Mater Misericordiae University Hospital, Dublin, Ireland
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Paul K. Marsden
1PET Imaging Centre, Imaging Sciences and Biomedical Engineering, St. Thomas’ Hospital, King’s College London, London, United Kingdom
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Ignac Fogelman
3Osteoporosis Screening and Research Unit, Imaging Sciences and Biomedical Engineering, Guy’s Hospital, King’s College London, London, United Kingdom
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Michelle L. Frost
3Osteoporosis Screening and Research Unit, Imaging Sciences and Biomedical Engineering, Guy’s Hospital, King’s College London, London, United Kingdom
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  • FIGURE 1.
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    FIGURE 1.

    Two user-defined landmarks required for segmentation are shown by arrows. Different regions at femur are defined by numbers 1–5.

  • FIGURE 2.
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    FIGURE 2.

    Segmented ROIs defined by semiautomatic technique. (A) Femoral-shaft ROI with cortical bone only forming hollow cylinder. (B) Femoral-neck ROI. (C) Total-hip ROI including trabecular and cortical bone of trochanter and femoral neck. ROIs are indicated by arrows. A color version of this figure is available as a supplemental file at http://tech.snmjournals.org.

  • FIGURE 3.
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    FIGURE 3.

    Two different examples of mean region (solid ovals) estimation using mean point–based distance between 2 regional boundaries (dashed ovals and dotted ovals). A color version of this figure is available as a supplemental file at http://tech.snmjournals.org.

  • FIGURE 4.
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    FIGURE 4.

    Mean time–activity curves generated from semiautomatically segmented ROIs. A color version of this figure is available as a supplemental file at http://tech.snmjournals.org.

Tables

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    TABLE 1

    Percentage Overlap and Differences Between Gold Standard and Semiautomatically Segmented ROIs

    Total hipFemoral neckFemoral shaft
    Gold standard vs. semiautomaticMeanSDMeanSDMeanSD
    Percentage overlap86.15.937.815.996.13.3
    Percentage difference14.512.589.744.24.76.0
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    TABLE 2

    Percentage Overlap and Differences Between Gold Standard (Mean of 8 Manually Drawn ROIs) and Manually Drawn ROIs (Each Separately Drawn Manual ROI)

    Total hipFemoral neckFemoral shaft
    Gold standard vs. manually drawn ROIMeanSDMeanSDMeanSD
    Percentage overlap85.242.939.124.395.247.8
    Percentage difference19.91591.661.412.225.3
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    TABLE 3

    Time to Draw ROIs Manually and Semiautomatically

    Total hipFemoral neckFemoral shaft
    Time (s)MeanSDMeanSDMeanSD
    Semiautomatic94.518.649.08.03.280.6
    Manual895.3371.9120.1100.1219.5168.9

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Journal of Nuclear Medicine Technology: 40 (3)
Journal of Nuclear Medicine Technology
Vol. 40, Issue 3
September 1, 2012
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Semiautomatic Region-of-Interest Validation at the Femur in 18F-Fluoride PET/CT
Tanuj Puri, Glen M. Blake, Kathleen M. Curran, Hamish Carr, Amelia E.B. Moore, Niall Colgan, Martin J. O’Connell, Paul K. Marsden, Ignac Fogelman, Michelle L. Frost
Journal of Nuclear Medicine Technology Sep 2012, 40 (3) 168-174; DOI: 10.2967/jnmt.111.100107

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Semiautomatic Region-of-Interest Validation at the Femur in 18F-Fluoride PET/CT
Tanuj Puri, Glen M. Blake, Kathleen M. Curran, Hamish Carr, Amelia E.B. Moore, Niall Colgan, Martin J. O’Connell, Paul K. Marsden, Ignac Fogelman, Michelle L. Frost
Journal of Nuclear Medicine Technology Sep 2012, 40 (3) 168-174; DOI: 10.2967/jnmt.111.100107
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