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OtherCONTINUING EDUCATION

Blood Volume Analysis: A New Technique and New Clinical Interest Reinvigorate a Classic Study

Timothy A. Manzone, Hung Q. Dam, Daniel Soltis and Vidya V. Sagar
Journal of Nuclear Medicine Technology June 2007, 35 (2) 55-63; DOI: https://doi.org/10.2967/jnmt.106.035972
Timothy A. Manzone
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Hung Q. Dam
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Daniel Soltis
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Vidya V. Sagar
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Figures

  • FIGURE 1. 
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    FIGURE 1. 

    Composition of blood and components of blood volume. Cellular components are suspended in plasma. Hematocrit (arrow) is fractional relationship between PV and RCV.

  • FIGURE 2. 
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    FIGURE 2. 

    Fluid exchanges through capillary membranes in formation and removal of interstitial fluid. (Reprinted with permission of (1).)

  • FIGURE 3. 
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    FIGURE 3. 

    Fluid balance. In health, fluid intake and fluid losses are about equal. Amounts shown are average adult daily fluid sources and losses. (Reprinted with permission of (2).)

  • FIGURE 4. 
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    FIGURE 4. 

    How indicator dilution technique is used to measure blood volume. Known quantity of tracer is administered (A), time is allowed for complete mixing (B), and blood sample is drawn for counting (C). Typical nuclear tracers are 51Cr-labeled erythrocytes (RBCs) and 125I-HSA.

  • FIGURE 5. 
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    FIGURE 5. 

    (A) Daxor BVA-100 blood volume analyzer. (B) Volumex injectate, containing 370–1,110 kBq (10–30 μCi) of 131I-HSA in exactly 1.0 mL of saline.

  • FIGURE 6. 
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    FIGURE 6. 

    BVA-100 results screen, showing sample counts (center), regression line (right), and final patient volume results (bottom) compared with ideal normal values.

  • FIGURE 7. 
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    FIGURE 7. 

    Detail of BVA-100 screen showing plot of individual blood volume results for timed samples. Regression line from this plot is extended back to y-axis at time 0 (arrow) to give final volume result.

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Journal of Nuclear Medicine Technology: 35 (2)
Journal of Nuclear Medicine Technology
Vol. 35, Issue 2
June 2007
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Blood Volume Analysis: A New Technique and New Clinical Interest Reinvigorate a Classic Study
Timothy A. Manzone, Hung Q. Dam, Daniel Soltis, Vidya V. Sagar
Journal of Nuclear Medicine Technology Jun 2007, 35 (2) 55-63; DOI: 10.2967/jnmt.106.035972
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  • Article
    • Abstract
    • OVERVIEW OF BLOOD VOLUME PHYSIOLOGY
    • BLOOD VOLUME MEASUREMENT AND THE INDICATOR DILUTION PRINCIPLE
    • MAKING THE ANALYSIS USEFUL: WHAT IS THE NORMAL VOLUME?
    • AUTOMATION COMES TO BLOOD VOLUME ANALYSIS
    • HOW IS THE TEST PERFORMED?
    • HOW ARE BLOOD VOLUME ANALYSIS RESULTS INTERPRETED?
    • NEW CLINICAL FRONTIERS FOR BLOOD VOLUME ANALYSIS
    • CONCLUSION
    • Footnotes
    • References
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Blood Volume Analysis: A New Technique and New Clinical Interest Reinvigorate a Classic Study
Timothy A. Manzone, Hung Q. Dam, Daniel Soltis, Vidya V. Sagar
Journal of Nuclear Medicine Technology Jun 2007, 35 (2) 55-63; DOI: 10.2967/jnmt.106.035972

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