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OtherCONTINUING EDUCATION

Clinical Applications of 18F-FDG in Oncology

Hani A. Nabi and José M. Zubeldia
Journal of Nuclear Medicine Technology March 2002, 30 (1) 3-9;
Hani A. Nabi
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José M. Zubeldia
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  • FIGURE 1.
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    FIGURE 1.

    Patient with history of carcinoma of left lung with left axillary lymph node metastases. 18F-FDG PET depicted other unsuspected metastatic sites in both axilla (arrow, right panel) and paratracheal nodes (arrow, center panel).

  • FIGURE 2.
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    FIGURE 2.

    Patient with right lower lobe nodule on CT (not shown) and adrenal mass on right side. 18F-FDG PET shows primary neoplasm in right lower lobe (arrow, left and right panels) and right adrenal gland metastases (arrow, middle panel).

  • FIGURE 3.
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    FIGURE 3.

    18F-FDG PET in presurgical staging of patients with colorectal cancer and hepatic metastases. This patient presented with history of adenocarcinoma of sigmoid colon and large liver lesion found on CT. PET showed liver metastases but no disease elsewhere. Patient was then considered for liver resection.

  • FIGURE 4.
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    FIGURE 4.

    Patient with history of squamous cell carcinoma of oropharynx who was sent for PET scan to assess response to treatment. PET scan showed 2 new lesions: 1 intrapulmonary (arrow, middle panel) and 1 in right upper ribs (arrow, left panel). In addition, primary tumor appeared unchanged.

  • FIGURE 5.
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    FIGURE 5.

    PET in staging of breast cancer. This patient presented with newly diagnosed breast carcinoma with suspected liver metastases. In addition, PET showed extensive lymph node involvement in right axilla (arrow), neck (bilaterally), and mediastinum (arrowhead).

Tables

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    TABLE 1

    18F-FDG PET vs. CT in Mediastinal Lymph Node Staging of Lung Cancer

    StudyImaging typeSensitivitySpecificityAccuracy
    Sasaki18F-FDG PET7610093
     et al. (15)Chest CT658782
    Wahl18F-FDG PET828181
     et al. (14)Chest CT644452
    Pieterman18F-FDG PET918687
     et al. (13)Chest CT756669
    • Data are percentages.

    • View popup
    TABLE 2

    18F-FDG PET in Surgical Management of Patients with Colorectal Cancer

    StudyNo. of patientsChange in management
    Beets et al. (25)14/23Avoided surgery in 6 patients
    Showed pelvic recurrence in 1 patient with rising carcinoembryonic antigen level
    Excluded pelvic recurrence in 3 patients
    Correctly depicted pelvic recurrence in 4 patients with equivocal findings on CT
    Ogunbiyi et al. (24)10/58Detected multiple hepatic lesions
    Schiepers et al. (54)11/76Detected 14 unexpected new lesions outside liver in 10 patients
    Found primary breast cancer in 1 patient
    Valk et al. (23)25/78Resulted in per-patient savings of $3,003
    • View popup
    TABLE 3

    18F-FDG PET in Other Malignancies

    Tumor typeResultsStudy
    MesotheliomaSensitivity, 91%Bénard et al. (55)
    Specificity, 100%
    Hepatic tumorsEarlier depiction of response to therapy with 18F-FDG than with CT or tumor markersNagata et al. (56)
    Germ cell carcinomaAccuracy of 90% in seminomas and 81% in nonseminomasCremerius et al. (57)
    Musculoskeletal sarcomaSensitivity, 81%Adler et al. (58)
    Specificity, 100%
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Journal of Nuclear Medicine Technology: 30 (1)
Journal of Nuclear Medicine Technology
Vol. 30, Issue 1
March 1, 2002
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Clinical Applications of 18F-FDG in Oncology
Hani A. Nabi, José M. Zubeldia
Journal of Nuclear Medicine Technology Mar 2002, 30 (1) 3-9;
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    • 18F-FDG as a Positron Emitter
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Clinical Applications of 18F-FDG in Oncology
Hani A. Nabi, José M. Zubeldia
Journal of Nuclear Medicine Technology Mar 2002, 30 (1) 3-9;

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