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Journal of Nuclear Medicine Technology

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Radiopharmacy

Technetium-99m MAG3: Labeling Conditions and Quality Control

Dennis L. Nosco, Robert G. Wolfangel, Michael J. Bushman, Glenn D. Grummon, Mary E. Marmion and David W. Pipes
Journal of Nuclear Medicine Technology June 1993, 21 (2) 69-74;
Dennis L. Nosco
Mallinckrodt Medical Inc., St. Louis, Missouri
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Robert G. Wolfangel
Mallinckrodt Medical Inc., St. Louis, Missouri
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Michael J. Bushman
Mallinckrodt Medical Inc., St. Louis, Missouri
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Glenn D. Grummon
Mallinckrodt Medical Inc., St. Louis, Missouri
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Mary E. Marmion
Mallinckrodt Medical Inc., St. Louis, Missouri
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David W. Pipes
Mallinckrodt Medical Inc., St. Louis, Missouri
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Abstract

TechneScan MAG3™, a radiopharmaceutical kit developed by Mallinckrodt Medical Inc., St. Louis, MO, for use in the evaluation of renal tubular function, was tested under a variety of labeling conditions. The effects of varying time (0–30 min) and heating temperature (90°C–110°C), technetium-99m activity (0–150 mCi) and volume (4–10 ml), timing and volume (0–10 ml) of air addition to the kit, and age of generator eluate (0–12 hr) used in reconstitution were examined. Analysis of the results from the above experiments show that, when used within the parameters described in the package insert, the reconstituted TechneScan MAG3 kit gives acceptable radiochemical purity (i.e., greater than 90%) every time. Of special note, results from these studies indicate that 99mTc generator eluate which has stood for more than 6 hr after elution should not be used to label the kits. A novel quality control method using a Cl8 Sep Pak (Millipore Corp., Milford, MA) is described. This method is easy and quick to perform and gives excellent accuracy, with results similar to those obtained using high performance liquid chromatography.

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Journal of Nuclear Medicine Technology: 21 (2)
Journal of Nuclear Medicine Technology
Vol. 21, Issue 2
June 1, 1993
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Technetium-99m MAG3: Labeling Conditions and Quality Control
Dennis L. Nosco, Robert G. Wolfangel, Michael J. Bushman, Glenn D. Grummon, Mary E. Marmion, David W. Pipes
Journal of Nuclear Medicine Technology Jun 1993, 21 (2) 69-74;

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Technetium-99m MAG3: Labeling Conditions and Quality Control
Dennis L. Nosco, Robert G. Wolfangel, Michael J. Bushman, Glenn D. Grummon, Mary E. Marmion, David W. Pipes
Journal of Nuclear Medicine Technology Jun 1993, 21 (2) 69-74;
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