False positive ⁶⁸Ga-DOTATATE PET-CT in Hereditary hypophosphatemic-osteomalacia mimicking culprit lesions of tumor induced osteomalacia

Abstract

The ⁶⁸Ga-DOTATATE PET-CT is an important imaging modality for detection of culprit lesion of tumor induced osteomalacia (TIO) in clinically symptomatic patient of hypophosphatemia-osteomalacia. Somatostatin receptor (SSTR) expression, may at times be observed in inflammatory/granulomatous conditions and fractures/degenerative bone disease leading to false positive scans finding. A rare case of hereditary hypophosphatemic-osteomalacia is presented, which showed increased false-positive uptake (for possible TIO lesions) in inflammatory condition of maxillary sinus and fracture of tibia in SSTR based ⁶⁸Ga-DOTATATE PET-CT.