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Journal of Nuclear Medicine Technology

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Abstract From Japan

The Effect of Cisplatin on Kidney Uptake of Technetium-99m-MDP in Rats

Tachio Sato, Seiro Yoshioka, Yoshinao Abe, Jutaro Takahashi, Kenji Yamada, Hiroshi Fukuda, Yuko Ogata, Masao Tada and Iku Burns
Journal of Nuclear Medicine Technology June 1996, 24 (2) 132-135;
Tachio Sato
Departments of Nuclear Medicine, Radiology and Molecular Neurology, Institute of Development, Aging and Cancer, Tohoku University and the Department of Radiology, Sendai Kosei Hospital, Sendai, Japan
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Seiro Yoshioka
Departments of Nuclear Medicine, Radiology and Molecular Neurology, Institute of Development, Aging and Cancer, Tohoku University and the Department of Radiology, Sendai Kosei Hospital, Sendai, Japan
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Yoshinao Abe
Departments of Nuclear Medicine, Radiology and Molecular Neurology, Institute of Development, Aging and Cancer, Tohoku University and the Department of Radiology, Sendai Kosei Hospital, Sendai, Japan
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Jutaro Takahashi
Departments of Nuclear Medicine, Radiology and Molecular Neurology, Institute of Development, Aging and Cancer, Tohoku University and the Department of Radiology, Sendai Kosei Hospital, Sendai, Japan
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Kenji Yamada
Departments of Nuclear Medicine, Radiology and Molecular Neurology, Institute of Development, Aging and Cancer, Tohoku University and the Department of Radiology, Sendai Kosei Hospital, Sendai, Japan
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Hiroshi Fukuda
Departments of Nuclear Medicine, Radiology and Molecular Neurology, Institute of Development, Aging and Cancer, Tohoku University and the Department of Radiology, Sendai Kosei Hospital, Sendai, Japan
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Yuko Ogata
Departments of Nuclear Medicine, Radiology and Molecular Neurology, Institute of Development, Aging and Cancer, Tohoku University and the Department of Radiology, Sendai Kosei Hospital, Sendai, Japan
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Masao Tada
Departments of Nuclear Medicine, Radiology and Molecular Neurology, Institute of Development, Aging and Cancer, Tohoku University and the Department of Radiology, Sendai Kosei Hospital, Sendai, Japan
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Iku Burns
Cardiovascular Associates of the Peninsula, San Francisco, California
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Abstract

Objective: The following experiments were performed to study the effect of cisplatin on the uptake of 99mTc-MDP in kidneys. There is renal accumulation of 99mTc-MDP bone imaging agents in patients treated with cisplatin.

Methods: Donryu rats weighing 150–160 g were administered 0.8 mg/kg of cisplatin intravenously for 7 days. On the day following the cisplatin injections and on the 37th day, we obtained 99mTc-MDP clearance from the blood and it showed two components: a fast and a slow component.

Results: On both the first and 37th days, the fast component of the cisplatin-treated group was identical to the control rats. On the contrary, the slow component of the cisplatin-treated group and control rats was 393.6 ± 116.4 min and 85.2 ± 19.9 min, (p < 0.001), respectively. On the 37th day, the slow components in both groups were not significantly different. Technetium-99m-MDP bone scanning was performed on the first, 15th and 37th days following cisplatin administration. The scintigram on the first day showed high uptake 99mTc-MDP in kidneys, bones and liver. On the 15th day, relatively high uptake in kidneys was observed. However, on the 37th day, 99mTc-MDP uptake of the kidneys returned to normal. The binding rate of 99mTc-MDP and 99mTc-MDP with cisplatin were 99.4 ± 0.6% and 79.0 ± 4.6%, respectively.

Conclusion: This study suggested that high renal uptake of 99mTc-MDP following administration of cisplatin was mainly due to delayed excretion of the radiopharmaceutical by binding with cisplatin.

  • technetium-99m-MDP
  • hot kidneys
  • cisplatin
  • binding rate
  • bone scintigraphy
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Journal of Nuclear Medicine Technology: 24 (2)
Journal of Nuclear Medicine Technology
Vol. 24, Issue 2
June 1, 1996
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The Effect of Cisplatin on Kidney Uptake of Technetium-99m-MDP in Rats
Tachio Sato, Seiro Yoshioka, Yoshinao Abe, Jutaro Takahashi, Kenji Yamada, Hiroshi Fukuda, Yuko Ogata, Masao Tada
Journal of Nuclear Medicine Technology Jun 1996, 24 (2) 132-135;

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The Effect of Cisplatin on Kidney Uptake of Technetium-99m-MDP in Rats
Tachio Sato, Seiro Yoshioka, Yoshinao Abe, Jutaro Takahashi, Kenji Yamada, Hiroshi Fukuda, Yuko Ogata, Masao Tada
Journal of Nuclear Medicine Technology Jun 1996, 24 (2) 132-135;
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Keywords

  • technetium-99m-MDP
  • hot kidneys
  • cisplatin
  • binding rate
  • bone scintigraphy
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