Airtight Miniaturized Chromatography: A Safer Method for Radiopharmaceutical Quality Control

Abstract

Miniaturized chromatography is widely used for quality control of radiopharmaceuticals. Recently, published chromatography procedures have illustrated or described chromatography chambers open to the air in use, suggesting that volatile toxic mobile phases are harmless to people in the vicinity. We describe the results of our search for an inexpensive closed chromatography chamber that can be used to derive safely the benefits from conventional miniaturized chromatography.