An Improved Method of Sulfur Colloid Radioaerosol Nebulization

Abstract

Radioaerosols have been used experimentally for a number of years as lung imaging agents. However, adherence of particles of rhenium-stabilized Tc-99m sulfur colloid within air-blast nebulizers has limited their usefulness. We have devised a method to reduce the surface charge on the particles, and thus their adherence, by addition of human serum albumin. This intervention does not alter the aerodynamic characteristics of the aerosol.