The Role of ¹⁸F-Sodium Fluoride PET/CT Bone Scans in the Diagnosis of Metastatic Bone Disease from Breast and Prostate Cancer

Abstract

We describe the role of ¹⁸F-sodium fluoride (¹⁸F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer. ¹⁸F-NaF PET was initially utilized as a bone scanning agent in the 1960s and early 1970s, however, its use was restricted by the then-available γ-cameras. The advent of hybrid PET/CT cameras in the late 1990s has shown a resurgence of interest in its use and role. After a brief introduction, this paper describes the radiopharmaceutical properties, dosimetry, pharmacokinetics, and mechanism of uptake of ¹⁸F-NaF. The performance of ¹⁸F-NaF PET/CT is then compared with that of conventional bone scintigraphy using current evidence from the literature. Strengths and weaknesses of ¹⁸F-NaF PET/CT imaging are highlighted. Clinical examples of improved accuracy of diagnosis and impact on patient management are illustrated. Limitations of ¹⁸F-NaF PET/CT imaging are outlined.