Fully automated production of diverse 18F-labeled PET tracers on the ELIXYS multireactor radiosynthesizer without hardware modification
Fully automated radiosynthesizers are continuing to be developed to meet the growing need
for the reliable production of PET tracers made under current good manufacturing practice …
for the reliable production of PET tracers made under current good manufacturing practice …
[HTML][HTML] ELIXYS-a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers
Background Automated radiosynthesizers are vital for routine production of positron-
emission tomography tracers to minimize radiation exposure to operators and to ensure …
emission tomography tracers to minimize radiation exposure to operators and to ensure …
[HTML][HTML] Simplified programming and control of automated radiosynthesizers through unit operations
Background Many automated radiosynthesizers for producing positron emission
tomography (PET) probes provide a means for the operator to create custom synthesis …
tomography (PET) probes provide a means for the operator to create custom synthesis …
A fully automated synthesis of [18F]‐FEAU and [18F]‐FMAU using a novel dual reactor radiosynthesis module
V Paolillo, S Riese, JG Gelovani… - Journal of Labelled …, 2009 - Wiley Online Library
Deoxy‐2′‐[18F] fluoro‐5‐substituted‐1‐β‐d‐arabinofuranosyluracils, including 2′‐deoxy‐
2′‐[18F] fluoro‐5‐methyl‐1‐β‐d‐arabinofuranosyluracil [18F] FMAU and [18F] FEAU are …
2′‐[18F] fluoro‐5‐methyl‐1‐β‐d‐arabinofuranosyluracil [18F] FMAU and [18F] FEAU are …
Automated synthesis modules for PET radiochemistry
L Bruton, PJH Scott - Handbook of radiopharmaceuticals …, 2020 - Wiley Online Library
The field of radiochemistry is constantly evolving to meet the needs for increased starting
amounts of radioactivity, and in the last couple of decades it has seen a move from manual …
amounts of radioactivity, and in the last couple of decades it has seen a move from manual …
Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis
AM Elizarov, RM Van Dam, YS Shin… - Journal of Nuclear …, 2010 - Soc Nuclear Med
An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp,
has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The …
has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The …
[HTML][HTML] A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms
C Barnes, M Nair, EO Aboagye, SJ Archibald… - Reaction Chemistry & …, 2022 - pubs.rsc.org
The automation of positron emission tomography (PET) radiochemistry using cassette-
based automated radiosynthesis platforms is an essential component of clinical translation …
based automated radiosynthesis platforms is an essential component of clinical translation …
Understanding temperatures and pressures during short radiochemical reactions
M Lazari, J Irribarren, S Zhang, RM van Dam - Applied Radiation and …, 2016 - Elsevier
Automated radiosynthesizers are critical for the reliable, routine production of PET tracers.
To perform reactions in these systems, the temperature of the reactor heater is controlled …
To perform reactions in these systems, the temperature of the reactor heater is controlled …
Automated production at the curie level of no‐carrier‐added 6‐[18F]fluoro‐ l‐dopa and 2‐[18F]fluoro‐ l‐tyrosine on a FASTlab synthesizer
C Lemaire, L Libert, X Franci, JL Genon… - Journal of Labelled …, 2015 - Wiley Online Library
An efficient, fully automated, enantioselective multi‐step synthesis of no‐carrier‐added (nca)
6‐[18F] fluoro‐L‐dopa ([18F] FDOPA) and 2‐[18F] fluoro‐L‐tyrosine ([18F] FTYR) on a GE …
6‐[18F] fluoro‐L‐dopa ([18F] FDOPA) and 2‐[18F] fluoro‐L‐tyrosine ([18F] FTYR) on a GE …
Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer
J Collins, CM Waldmann, C Drake… - Proceedings of the …, 2017 - National Acad Sciences
New radiolabeled probes for positron-emission tomography (PET) are providing an ever-
increasing ability to answer diverse research and clinical questions and to facilitate the …
increasing ability to answer diverse research and clinical questions and to facilitate the …