99mTc-Tilmanocept: a novel molecular agent for lymphatic mapping and sentinel lymph node localization

DS Surasi, J O'Malley… - Journal of nuclear …, 2015 - Soc Nuclear Med
Preoperative lymphatic mapping in conjunction with intraoperative γ-probe detection is
widely used for sentinel node localization in melanoma, breast cancer, and other …

A Phase 2 Study of 99mTc-Tilmanocept in the Detection of Sentinel Lymph Nodes in Melanoma and Breast Cancer

SPL Leong, J Kim, M Ross, M Faries… - Annals of surgical …, 2011 - Springer
Abstract Background Several 99m Tc-labeled agents that are not approved by the US Food
and Drug Administration are used for lymphatic mapping. A new low-molecular-weight …

Mapping lymph nodes in cancer management – role of 99mTc-tilmanocept injection

C Tausch, A Baege, C Rageth - OncoTargets and therapy, 2014 - Taylor & Francis
Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into
surgical cancer management and was termed sentinel node navigated surgery. Although …

[HTML][HTML] Detection of melanoma, breast cancer and head and neck squamous cell cancer sentinel lymph nodes by Tc-99m Tilmanocept (LymphoseekŪ)

SP Leong - Clinical & Experimental Metastasis, 2022 - Springer
Technetium-99m-labeled Tilmanocept or LymphoseekŪ(Cardinal Health, Dublin, Ohio) is a
soluble, synthetic molecule with a small diameter (7 nm), which is comprised of technetium …

[HTML][HTML] A tri-modal molecular imaging agent for sentinel lymph node mapping

Z Qin, CK Hoh, DJ Hall, DR Vera - Nuclear Medicine and Biology, 2015 - Elsevier
Introduction We report an “instant kit” method to radiolabel fluorescent-tilmanocept with 68
Ga and 99m Tc for tri-modal molecular imaging of sentinel lymph nodes (SLNs). Methods …

99mTc-Tilmanocept performance for sentinel node mapping in breast cancer, melanoma, and head and neck cancer: a systematic review and meta-analysis from a …

G Rovera, EJ de Koster, V Rufini, M Zollino… - European Journal of …, 2023 - Springer
Purpose Although multiple radiopharmaceuticals are currently available for sentinel node
(SN) biopsy, 99mTc-tilmanocept is of particular interest due to its low molecular weight and …

Next generation of radiotracers for sentinel lymph node biopsy: what is still necessary to establish new imaging paradigms?

S Vidal-Sicart, DR Vera, RAV Olmos - Revista Espaņola de Medicina …, 2018 - Elsevier
Sentinel lymph node (SLN) biopsy is now the standard of care for regional staging in several
solid tumors. The interstitial administration of a radiotracer around the primary tumor provide …

In vivo evaluation of three different 99mTc-labelled radiopharmaceuticals for sentinel lymph node identification

MM Edreira, LL Colombo, JH Perez… - Nuclear medicine …, 2001 - journals.lww.com
This work was designed to compare sentinel lymph node (SLN) uptake of 99m Tc-labelled
human serum albumin colloid (99m Tc-HSAC), 99m Tc-labelled antimony sulphur colloid …

[HTML][HTML] γ-Tilmanocept, a new radiopharmaceutical tracer for cancer sentinel lymph nodes, binds to the mannose receptor (CD206)

AK Azad, MVS Rajaram, WL Metz, FO Cope… - The Journal of …, 2015 - journals.aai.org
Abstract γ-Tilmanocept (99m Tc-labeled-tilmanocept or [99m Tc]-tilmanocept) is the first
mannose-containing, receptor-directed, radiolabeled tracer for the highly sensitive imaging …

Lymphoseek: a molecular imaging agent for melanoma sentinel lymph node mapping

AM Wallace, CK Hoh, SJ Ellner, DD Darrah… - Annals of surgical …, 2007 - Springer
Background Lymphoseek is a molecular imaging agent specifically designed for sentinel
lymph node mapping. We conducted a phase I clinical trial in which Lymphoseek was …