Evaluation of an alternative radiochemical purity testing method for technetium-99m-sestamibi

AL Luebke, DM Wilary, DW Mahoney… - Journal of Nuclear …, 2000 - Soc Nuclear Med
Objective: Our study evaluated the accuracy and reliability of 3 radiochemical purity (RCP)
measurement methods of 99mTc-sestamibi. A regular-sized (1.0 cm× 9.0 cm) Whatman 31 …

Comparison of four alternative radiochemical purity testing methods for 99Tcm-sestamibi

JC Hung, ME Wilson, MW Gebhard… - Nuclear medicine …, 1995 - journals.lww.com
Four different methods for determining the radiochemical purity (RCP) of 99 Tc m-sestamibi
have been proposed to replace the recommended thin-layer chromatography (TLC) method …

The effect of selected preparation variables on the radiochemical purity of 99mTc-sestamibi

JP Norenberg, MP Vaidya, WB Hladik… - Journal of nuclear …, 2005 - Soc Nuclear Med
Objective: Measurement of cardiac perfusion via agents such as 99mTc-sestamibi
(Cardiolite; DuPont-Merck Pharmaceutical Co., Inc.) is widely used in clinical nuclear …

The presence of sodium nitrate in generator eluate decreases the radiochemical purity of 99mTc-sestamibi

T Métayé, T Rosenberg, J Guilhot… - Journal of nuclear …, 2012 - Soc Nuclear Med
A high radiochemical purity (RCP) is recommended for radiopharmaceutical compounds
used in the clinical practice of nuclear medicine. However, some preparations of 99mTc …

Rapid quality control of 99Tcm-sestamibi

RM Reilly, M So, J Polihronis… - Nuclear medicine …, 1992 - journals.lww.com
The thin layer chromatographic (TLC) method for determining the radiochemical purity of 99
Tc m-sestamibi suggested by the manufacturer of the kit is slow and inconvenient. In this …

The influence of generator eluate on the radiochemical purity of 99Tcm-sestamibi prepared using fractionated Cardiolite® kits

P Varelis, SL Parkes, MT Poot - Nuclear medicine …, 1998 - journals.lww.com
The reconstitution of fractionated Cardiolite® kits with sodium 99 Tc m-pertechnetate eluted
from a wet-column 99 Mo/99 Tc m generator results in a preparation that contains elevated …

Generator eluate effects on the labeling efficiency of 99mTc-sestamibi

JC Hung, TJ Herold, ME Wilson, RJ Gibbons - Nuclear medicine and …, 1995 - Elsevier
Our nuclear pharmacy noted that 99mTc-sestamibi kits sometimes failed radiochemical
purity (RCP) testing (ie, RCP< 90%). All failed kits had been prepared with eluate from a …

A miniaturized rapid paper chromatographic procedure for quality control of technetium-99m sestamibi

M Patel, S Sadek, S Jahan, A Owunwanne - European journal of nuclear …, 1995 - Springer
A miniaturized rapid paper chromatographic technique (MRPC) for quality control of a
technetium-99m sestamibi preparation was developed and compared with the …

Optimal conditions of 99mTc eluate for the radiolabeling of 99mTc-sestamibi

JC Hung, TJ Herold, RJ Gibbons - Nuclear medicine and biology, 1996 - Elsevier
Our nuclear pharmacy has reported that a failed radiochemical purity (RCP)(ie, RCP< 90%)
of 99mTc-sestamibi may be associated with the use of a first elution at later stages from a …

Radio-UHPLC: A tool for rapidly determining the radiochemical purity of technetium-99m radiopharmaceuticals?

D Kryza, M Janier - Applied Radiation and Isotopes, 2013 - Elsevier
Determining the radiochemical purity (RCP) of technetium-99m (99mTc)
radiopharmaceuticals using the method described in the package insert is a time-consuming …