Parkinson's disease (PD) is a progressive, degenerative disorder that affects 10 million
people worldwide. More than 90% of individuals with PD develop hypokinetic dysarthria, a …

Purpose A cut-off of-2 z-score for striatal or putaminal SBR has been to date arbitrarily used
to define an abnormal DaT SPECT in patients with suspected neurodegenerative …

Background Idiopathic normal pressure hydrocephalus and PSP share several clinical and
radiological features, making differential diagnosis, at times, challenging. Objectives To …

Assessing imaging biomarker in the prodromal and early phases of Parkinson's disease
(PD) is of great importance to ensure an early and safe diagnosis. In the last decades …

Background Mild cognitive impairment (MCI) is frequently diagnosed in patients with
isolated rapid eye movement (REM) sleep behavior disorder (iRBD), although the extent of …

Aim [123] I-Ioflupane (DaTSCAN) binds to the presynaptic dopamine transporter (DAT) and
with a lower affinity to the serotonin transporter (SERT). We aimed to develop a novel …

Reduced nigrostriatal uptake on N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-[123 I]
iodophenyl) nortropane (123 I-FP-CIT) SPECT reflects dopamine dysfunction, while other …

Introduction In this research, our primary objective was to explore the correlation between
basal ganglia dopaminergic neurotransmission, assessed using 123I-FP-CIT (DAT-SPECT) …

Background A hallmark of Parkinson's disease (PD) is progressive loss of dopamine
terminals in the basal ganglia, with clinical symptoms including motor and non‐motor …

Objectives: Explain the pathophysiology of essential tremor. Describe how essential tremor
can impact a patient's livelihood. Summarize the management strategies for essential …