Integrins are cell adhesion and signalling proteins crucial to a wide range of biological
functions. Effective marketed treatments have successfully targeted integrins αIIbβ3 …

Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …

Phase 0 approaches—which include microdosing—evaluate subtherapeutic exposures of
new drugs in first-in-human studies known as exploratory clinical trials. Recent progress …

Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with
poor prognosis and a significant unmet medical need. This study evaluated the safety …

Purpose: The study was undertaken to develop and evaluate the potential of an integrin
αvβ6-binding peptide (αvβ6-BP) for noninvasive imaging of a diverse range of malignancies …

Tumor-homing peptides are widely used for improving tumor selectivity of anticancer drugs
and imaging agents. The goal is to increase tumor uptake and reduce accumulation at …

Interstitial lung disease is an overarching term for a wide range of disorders characterized by
inflammation and/or fibrosis in the lungs. Most prevalent forms, among others, include …

Active targeting of tumors is believed to be the key to efficient cancer therapy and accurate,
early-stage diagnostics. Active targeting implies minimized off-targeting and associated …

The overexpression of integrin αvβ6 in pancreatic cancer makes it a promising target for
noninvasive PET imaging. However, currently, most integrin αvβ6–targeting radiotracers are …