[HTML][HTML] Bile reflux and hypopharyngeal cancer

DP Vageli, SG Doukas, PG Doukas… - Oncology …, 2021 - spandidos-publications.com
Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …

[HTML][HTML] Weakly acidic bile is a risk factor for hypopharyngeal carcinogenesis evidenced by DNA damage, antiapoptotic function, and premalignant dysplastic lesions …

CT Sasaki, SG Doukas, PG Doukas, DP Vageli - Cancers, 2021 - mdpi.com
Simple Summary The etiologic role of biliary reflux in hypopharyngeal cancer is supported
by clinical data. Although, reflux episodes often occur at pH 4.0, they can also occur at …

Biliary leak in the postsurgical abdomen: a primer to HIDA scan interpretation

M Matesan, M Bermo, I Cruite, CH Shih… - Seminars in nuclear …, 2017 - Elsevier
Postsurgical bile leaks can be associated with significant morbidity and even mortality, if not
identified and treated at an early phase. Hepatobiliary iminodiacetic acid (HIDA) scan is an …

Curcumin prevents the bile reflux‐induced NF‐κB‐related mRNA oncogenic phenotype, in human hypopharyngeal cells

DP Vageli, SG Doukas, T Spock… - Journal of cellular and …, 2018 - Wiley Online Library
The presence of bile is not an uncommon finding in acidic oesophageal and extra‐
oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to …

Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo

DP Vageli, PG Doukas, SG Doukas, A Tsatsakis… - Cancer Prevention …, 2022 - AACR
Tobacco smoking is the most known risk factor for hypopharyngeal cancer. Bile reflux has
recently been documented as an independent risk factor for NFκB-mediated …

Renaissance in peptide drug discovery: the third wave

TK Sawyer - 2017 - books.rsc.org
Chapter 1 2 mechanisms and peptide drug delivery, including cell permeability to prosecute
intracellular targets, is re-defining the term “druggability”. Beyond such convergent …

The in vivo preventive and therapeutic properties of curcumin in bile reflux‐related oncogenesis of the hypopharynx

SG Doukas, PG Doukas, CT Sasaki… - Journal of Cellular and …, 2020 - Wiley Online Library
Bile at strongly acidic pH exerts a carcinogenic effect on the hypopharynx, based upon
recent pre‐clinical studies that support its role as an independent risk factor. We recently …

[HTML][HTML] Inhibition of NF-κB prevents the acidic bile-induced oncogenic mRNA phenotype, in human hypopharyngeal cells

DP Vageli, SG Doukas, CT Sasaki - Oncotarget, 2018 - ncbi.nlm.nih.gov
Bile-containing gastro-duodenal reflux has been clinically considered an independent risk
factor in hypopharyngeal carcinogenesis. We recently showed that the chronic effect of …

[HTML][HTML] The progressive mutagenic effects of acidic bile refluxate in hypopharyngeal squamous cell carcinogenesis: new insights

CT Sasaki, SG Doukas, J Costa, DP Vageli - Cancers, 2020 - mdpi.com
Cancers of the laryngopharynx represent the most devastating of the head and neck
malignancies and additional risk factors are now epidemiologically linked to this disease …

The Role of PARP‐1 and NF‐κB in Bile‐Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells

PG Doukas, DP Vageli, BL Judson - The Laryngoscope, 2023 - Wiley Online Library
Objectives/Hypothesis We recently documented that acidic bile, a gastroesophageal reflux
content, can cause invasive hypopharyngeal squamous cell carcinoma, by inducing …