[HTML][HTML] Bile reflux and hypopharyngeal cancer
Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …
considered a risk factor in the development of hypopharyngeal cancer. Bile acids are …
[HTML][HTML] Weakly acidic bile is a risk factor for hypopharyngeal carcinogenesis evidenced by DNA damage, antiapoptotic function, and premalignant dysplastic lesions …
Simple Summary The etiologic role of biliary reflux in hypopharyngeal cancer is supported
by clinical data. Although, reflux episodes often occur at pH 4.0, they can also occur at …
by clinical data. Although, reflux episodes often occur at pH 4.0, they can also occur at …
Biliary leak in the postsurgical abdomen: a primer to HIDA scan interpretation
M Matesan, M Bermo, I Cruite, CH Shih… - Seminars in nuclear …, 2017 - Elsevier
Postsurgical bile leaks can be associated with significant morbidity and even mortality, if not
identified and treated at an early phase. Hepatobiliary iminodiacetic acid (HIDA) scan is an …
identified and treated at an early phase. Hepatobiliary iminodiacetic acid (HIDA) scan is an …
Curcumin prevents the bile reflux‐induced NF‐κB‐related mRNA oncogenic phenotype, in human hypopharyngeal cells
The presence of bile is not an uncommon finding in acidic oesophageal and extra‐
oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to …
oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to …
Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo
Tobacco smoking is the most known risk factor for hypopharyngeal cancer. Bile reflux has
recently been documented as an independent risk factor for NFκB-mediated …
recently been documented as an independent risk factor for NFκB-mediated …
Renaissance in peptide drug discovery: the third wave
TK Sawyer - 2017 - books.rsc.org
Chapter 1 2 mechanisms and peptide drug delivery, including cell permeability to prosecute
intracellular targets, is re-defining the term “druggability”. Beyond such convergent …
intracellular targets, is re-defining the term “druggability”. Beyond such convergent …
The in vivo preventive and therapeutic properties of curcumin in bile reflux‐related oncogenesis of the hypopharynx
Bile at strongly acidic pH exerts a carcinogenic effect on the hypopharynx, based upon
recent pre‐clinical studies that support its role as an independent risk factor. We recently …
recent pre‐clinical studies that support its role as an independent risk factor. We recently …
[HTML][HTML] Inhibition of NF-κB prevents the acidic bile-induced oncogenic mRNA phenotype, in human hypopharyngeal cells
Bile-containing gastro-duodenal reflux has been clinically considered an independent risk
factor in hypopharyngeal carcinogenesis. We recently showed that the chronic effect of …
factor in hypopharyngeal carcinogenesis. We recently showed that the chronic effect of …
[HTML][HTML] The progressive mutagenic effects of acidic bile refluxate in hypopharyngeal squamous cell carcinogenesis: new insights
Cancers of the laryngopharynx represent the most devastating of the head and neck
malignancies and additional risk factors are now epidemiologically linked to this disease …
malignancies and additional risk factors are now epidemiologically linked to this disease …
The Role of PARP‐1 and NF‐κB in Bile‐Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells
Objectives/Hypothesis We recently documented that acidic bile, a gastroesophageal reflux
content, can cause invasive hypopharyngeal squamous cell carcinoma, by inducing …
content, can cause invasive hypopharyngeal squamous cell carcinoma, by inducing …