Several FDA/EMA‐approved nanomedicines have demonstrated improved
pharmacokinetics and toxicity profiles compared to their conventional chemotherapeutic …

Purpose Although lymphocyte activation gene-3 (LAG-3) directed therapies demonstrate
promising clinical anti-cancer activity, only a subset of patients seems to benefit and …

Abstract γ-Aminobutyric acid (GABA A) receptors are thought to play an important role in
modulating the central nervous system in response to stress. Animal data have shown …

Purpose: To evaluate whether, in patients with non–small cell lung carcinoma (NSCLC),
tumor uptake of [11C] erlotinib can be quantified and imaged using positron emission …

The purpose of the present study was to evaluate the performance of various parametric
reference tissue models for quantification of [11C] PIB studies. Several models with and …

(R)-[11C] PK11195 ([1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl]-3-isoquinoline
carboxamide) is a ligand for the peripheral benzodiazepine receptor, which, in the brain, is …

Quantitative assessment of 11C-erlotinib uptake may be useful in selecting non–small cell
lung cancer (NSCLC) patients for erlotinib therapy. The purpose of this study was to find the …

The purpose of this study was to compare different kinetic and semi-quantitative methods for
analysing human [18F] FP-β-CIT studies: plasma input models, simplified (SRTM) and full …

Purpose Different pharmacokinetic methods for [18 F] FDDNP studies were evaluated using
both simulations and clinical data. Procedures Methods included two-tissue reversible …

Nuclear medicine emerged in the late 19th century with the discovery of radioactivity, which
is now widely used in both diagnostic imaging and therapeutics.[1] A vital tool in nuclear …