Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease

R De la Fuente-Fernández, TJ Ruth, V Sossi… - Science, 2001 - science.org
The power of placebos has long been recognized for improving numerous medical
conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism …

In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease

CS Lee, A Samii, V Sossi, TJ Ruth… - Annals of Neurology …, 2000 - Wiley Online Library
Clinical symptoms of Parkinson's disease (PD) do not manifest until dopamine (DA)
neuronal loss reaches a symptomatic threshold. To explore the mechanisms of functional …

Studies of the Uptake of Nitrate in Barley: I. Kinetics of 13NO3 Influx

MY Siddiqi, ADM Glass, TJ Ruth, TW Rufty Jr - Plant physiology, 1990 - academic.oup.com
13 NO 3 − was used to investigate patterns of NO 3 − influx into roots of barley plants (Hordeum
vulgare L. cv Klondike) previously grown with (`induced') or without (`uninduced') a …

Levodopa-induced changes in synaptic dopamine levels increase with progression of Parkinson's disease: implications for dyskinesias

…, Z Huang, S Furtado, JQ Lu, DB Calne, TJ Ruth… - Brain, 2004 - academic.oup.com
Peak-dose dyskinesias are abnormal movements that usually occur 1 h after oral
administration of levodopa, and often complicate chronic treatment of Parkinson's disease. We …

Ammonium uptake by rice roots (II. Kinetics of 13NH4+ influx across the plasmalemma)

MY Wang, MY Siddiqi, TJ Ruth, ADM Glass - Plant physiology, 1993 - academic.oup.com
Short-term influxes of 13NH4+ were measured in intact roots of 3-week-old rice (Oryza
sativa L. cv M202) seedlings that were hydroponically grown at 2, 100, or 1000 [mu]M NH4+. …

Dopamine release in human ventral striatum and expectation of reward

…, M Zamburlini, V Sossi, DB Calne, TJ Ruth… - Behavioural brain …, 2002 - Elsevier
Using the ability of [ 11 C]raclopride to compete with dopamine for D 2 /D 3 receptors, we
investigated by positron emission tomography the effect of placebo (saline) injection on …

Effects of expectation on placebo-induced dopamine release in Parkinson disease

…, K Dinelle, E Mak, V Sossi, TJ Ruth… - Archives of general …, 2010 - jamanetwork.com
Context Expectations play a central role in the mechanism of the placebo effect. In Parkinson
disease (PD), the placebo effect is associated with release of endogenous dopamine in …

Age‐dependent decline of dopamine D1 receptors in human brain: A PET study

…, E Mak, M Schulzer, JM Huser, BJ Snow, TJ Ruth… - Synapse, 1998 - Wiley Online Library
Radioligand binding studies in animals have demonstrated age‐related loss of dopamine
receptors in the caudate and putamen. In humans, while age‐related declines in dopamine …

Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease: PET evidence of increased dopamine turnover

…, M Schulzer, JE Holden, CS Lee, TJ Ruth… - Annals of …, 2001 - Wiley Online Library
Motor fluctuations are a major disabling complication in the treatment of Parkinson's disease.
To investigate whether such oscillations in mobility can be attributed to changes in the …

PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation

…, E Mak, J Mckenzie, A Strongosky, V Sossi, TJ Ruth… - Brain, 2005 - academic.oup.com
Parkinson's disease may arise from multiple aetiologies, including genetic mutations that
are for the most part uncommon. We describe here the positron emission tomography (PET) …