Background— Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal
cardiomyopathy for which several promising therapies are in development. The diagnosis is …

Background— Impaired vasodilator function is an early manifestation of coronary artery
disease and may precede angiographic stenosis. It is unknown whether noninvasive …

Objectives : This study sought to relate imaging findings on positron emission tomography (PET)
to adverse cardiac events in patients referred for evaluation of known or suspected …

The amyloidoses are a group of protein-folding disorders in which ≥1 organ is infiltrated by
proteinaceous deposits known as amyloid. The deposits are derived from 1 of several …

Background— Coronary microvascular dysfunction (CMD) is a prevalent and prognostically
important finding in patients with symptoms suggestive of coronary artery disease. The …

Angiographic severity of coronary artery stenosis has historically been the primary guide to
revascularization or medical management of coronary artery disease. However, physiologic …

Background— Diabetes mellitus increases the risk of adverse cardiac outcomes and is
considered a coronary artery disease (CAD) equivalent. We examined whether coronary …

Stress-induced myocardial perfusion defects have been firmly established as an important
diagnostic and prognostic technique for identifying flow-limiting epicardial coronary artery …

Cardiac amyloidosis is a form of restrictive infiltrative cardiomyopathy that confers significant
mortality. Due to the relative rarity of cardiac amyloidosis, clinical and diagnostic expertise …

Aims Coronary microvascular ischaemia, cardiomyocyte injury and stiffness may play an
important role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). …