Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor
symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. We …

It takes effort and time to tame one's impulses. Although medial prefrontal cortex (mPFC) is
broadly implicated in effortful control over behavior, the subthalamic nucleus (STN) is …

Background Transdermal nicotine therapy is widely used to aid smoking cessation, but there
is uncertainty about its safety in patients with cardiac disease. Methods In a randomized, …

Background Coronary electron beam computed tomography (EBCT) detects atherosclerotic
coronary artery disease by measuring calcium deposition in the walls of coronary arteries. …

Objective: To evaluate the effectiveness and safety of bupropion sustained-release (SR) for
the treatment of neuropathic pain. Method: This single-center, outpatient, randomized, double…

Background and Aims The ageing US population is providing an unprecedented population
of older adults who use recreational drugs. We aimed to estimate the trends in the …

Background Alcohol use is common among older adults, and this population has unique risks
with alcohol consumption in even lower amounts than younger persons. No recent studies …

Large-scale multi-ethnic cohorts offer unprecedented opportunities to elucidate the genetic
factors influencing complex traits related to health and disease among minority populations. …

Parkinson's disease (PD) patients exhibit cognitive deficits, including reinforcement learning,
working memory (WM) and set shifting. Computational models of the basal ganglia–frontal …

Background Physicians are encouraged to counsel obese patients to lose weight, but studies
measuring the quality of physicians' counseling are rare. We sought to describe the quality …