The identification of genetic causes for Mendelian disorders has been based on the collection
of multi-incident families, linkage analysis, and sequencing of genes in candidate intervals…

Background Multiple system atrophy (MSA) is a fatal and still poorly understood degenerative
movement disorder that is characterised by autonomic failure, cerebellar ataxia, and …

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages dopaminergic neurons in the
substantia nigra pars compacta (SNpc) as seen in Parkinson's disease. Here, we show that …

The motor symptoms of Parkinson's disease are predominantly due to progressive
degeneration of nigral dopaminergic neurons. In most cases there is a substantial asymmetry of …

MPTP causes damage to substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons
as seen in Parkinsons disease (PD). After sys-temic administration of MPTP, its active …

Endothelins are a recently discovered group of most powerful vasoconstrictor peptides.
Endothelin-1 is produced by endothelial cells, and endothelin-3 is derived from neuronal tissue. …

Multiple system atrophy (MSA) is a Parkinson's Disease (PD)‐like α‐synucleinopathy clinically
characterized by dysautonomia, parkinsonism, cerebellar ataxia, and pyramidal signs in …

The clinical diagnosis of multiple system atrophy (MSA) is fraught with difficulty and there
are no pathognomonic features to discriminate the parkinsonian variant (MSA‐P) from …

Camptocormia is characterized by severe forward flexion of the thoracolumbar spine which
increases while walking and disappears in the recumbent position. We describe for the first …

Objective The use of cannabis as a therapeutic agent for various medical conditions has
been well documented. However, clinical trials in patients with Parkinson disease (PD) have …