The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds
with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ) peptide in vitro. The in …

While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

Antibodies to α‐synuclein (AS) now provide a sensitive and specific method for the
detection of Lewy bodies (LBs) and their use will allow a more accurate determination of the …

In response to oxidative stress, the nuclear factor E2-related factor 2 (Nrf2) transcription factor
translocates from the cytoplasm into the nucleus and transactivates expression of genes …

Purpose A phase I/II trial was performed to evaluate the safety and immunogenicity of a novel
vaccination with α-type 1 polarized dendritic cells (αDC1) loaded with synthetic peptides …

OBJECTIVE: We present the second reported case of autopsy-confirmed chronic traumatic
encephalopathy in a retired professional football player, with neuropathological features that …

Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile
dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) …

Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by …

We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the
genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal …