[HTML][HTML] Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
Diet and the gut microbiota may underpin numerous human diseases. A major metabolic
product of commensal bacteria are short-chain fatty acids (SCFAs) that derive from …
product of commensal bacteria are short-chain fatty acids (SCFAs) that derive from …
Tissue-specific expression of a wheat high molecular weight glutenin gene in transgenic tobacco.
LS Robert, RD Thompson, RB Flavell - The Plant Cell, 1989 - academic.oup.com
The expression of a wheat genomic clone containing the entire coding sequence of the high
molecular weight glutenin subunit 12 gene flanked by 2.6 kilobases of 5' and 1.5 kilobases …
molecular weight glutenin subunit 12 gene flanked by 2.6 kilobases of 5' and 1.5 kilobases …
T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells
…, L Gorelik, SD Hurst, RL Coffman, RA Flavell… - The Journal of …, 2005 - rupress.org
CD4 + CD25 + regulatory T (T reg) cells play a pivotal role in control of the immune response.
Transforming growth factor-β (TGF-β) has been shown to be required for T reg cell activity; …
Transforming growth factor-β (TGF-β) has been shown to be required for T reg cell activity; …
JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration
…, M Rzhetskaya, N Kholodilov, RA Flavell… - Journal of …, 2008 - Wiley Online Library
Activation of c‐jun N‐terminal kinase (JNK) by the mitogen‐activated protein kinase
cascade has been shown to play an important role in the death of dopamine neurons of the …
cascade has been shown to play an important role in the death of dopamine neurons of the …
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
…, S Mohanty, M Trentalange, RJ Homer, RA Flavell… - Science, 2016 - science.org
Influenza A virus (IAV) causes up to half a million deaths worldwide annually, 90% of which
occur in older adults. We show that IAV-infected monocytes from older humans have …
occur in older adults. We show that IAV-infected monocytes from older humans have …
Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-β sensitivity in vitro and in vivo
EA Wohlfert, L Gorelik, R Mittler, RA Flavell… - The Journal of …, 2006 - journals.aai.org
Mice deficient in the E3 ubiquitin ligase Cbl-b have CD28-independent T cells and develop
autoimmunity. We previously reported that Cbl-b−/− CD4+ CD25− T effector cells are …
autoimmunity. We previously reported that Cbl-b−/− CD4+ CD25− T effector cells are …
HIV infection is blocked in vitro by recombinant soluble CD4
The T-cell surface glycoprotein, CD4 (T4), acts as the cellular receptor for human
immunodeficiency virus, type 1 (HIV-1), the first member of the family of viruses that cause acquired …
immunodeficiency virus, type 1 (HIV-1), the first member of the family of viruses that cause acquired …
Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells
Memory CD8 + T cells are critical for host defense upon reexposure to intracellular pathogens.
We found that interleukin 10 (IL-10) derived from CD4 + regulatory T cells (T reg cells) …
We found that interleukin 10 (IL-10) derived from CD4 + regulatory T cells (T reg cells) …
Estrogen prevents bone loss through transforming growth factor β signaling in T cells
Estrogen (E) deficiency leads to an expansion of the pool of tumor necrosis factor (TNF)-producing
T cells through an IFN-γ-dependent pathway that results in increased levels of the …
T cells through an IFN-γ-dependent pathway that results in increased levels of the …
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a
stable latent reservoir 1 , 2 , primarily in resting memory CD4 + T cells 3 , 4 . This reservoir …
stable latent reservoir 1 , 2 , primarily in resting memory CD4 + T cells 3 , 4 . This reservoir …