Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling
…, P Arrazola, O Hino, T Kobayashi, RS Yeung… - Nature cell …, 2002 - nature.com
Target of Rapamycin (TOR) mediates a signalling pathway that couples amino acid availability
to S6 kinase (S6K) activation, translational initiation and cell growth 1 , 2 . Here, we show …
to S6 kinase (S6K) activation, translational initiation and cell growth 1 , 2 . Here, we show …
[HTML][HTML] Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: a role for the TSC2 tumor suppressor gene in pulmonary …
…, DS Hunter, MK Glassberg, RS Yeung… - Journal of Biological …, 2002 - ASBMB
Although the cellular functions ofTSC2 and its protein product, tuberin, are not known, somatic
mutations in the TSC2 tumor suppressor gene are associated with tumor development in …
mutations in the TSC2 tumor suppressor gene are associated with tumor development in …
[HTML][HTML] Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
…, XM Sui, CC Ou, M Nellist, RS Yeung… - Journal of Biological …, 2002 - ASBMB
Normal cellular functions of hamartin and tuberin, encoded by the TSC1 and TSC2tumor
suppressor genes, are closely related to their direct interactions. However, the regulation of the …
suppressor genes, are closely related to their direct interactions. However, the regulation of the …
[HTML][HTML] The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis
…, F Shoarinejad, F Jin, EA Golemis, RS Yeung - Journal of Biological …, 1997 - ASBMB
The tuberous sclerosis complex 2 (TSC2) is a tumor suppressor gene that plays a causative
role in the autosomal dominant syndrome of tuberous sclerosis. The latter is characterized …
role in the autosomal dominant syndrome of tuberous sclerosis. The latter is characterized …
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
HL Kenerson, LD Aicher, LD True, RS Yeung - Cancer research, 2002 - AACR
… Yeung’s laboratory for critical reading and suggestions. We are grateful to David Ewalt, Lisa
… Aicher LD, Campbell JS, Yeung RS Tuberin phosphorylation regulates its interaction with …
… Aicher LD, Campbell JS, Yeung RS Tuberin phosphorylation regulates its interaction with …
Axillary web syndrome after axillary dissection
AH Moskovitz, BO Anderson, RS Yeung… - The American journal of …, 2001 - Elsevier
Background: Some patients undergoing axillary lymph node dissection (ALND) experience
postoperative pain and limited range of motion associated with a palpable web of tissue …
postoperative pain and limited range of motion associated with a palpable web of tissue …
Increased false negative sentinel node biopsy rates after preoperative chemotherapy for invasive breast carcinoma
…, RA Schmidt, KD Jewell, RS Yeung… - … Journal of the …, 2000 - Wiley Online Library
BACKGROUND Sentinel lymph node dissection (SLND) has been a promising new
technique in breast carcinoma staging, but could be unreliable in certain patient subsets. The …
technique in breast carcinoma staging, but could be unreliable in certain patient subsets. The …
Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms
H Kenerson, AL Folpe, TK Takayama, RS Yeung - Human pathology, 2007 - Elsevier
Angiomyolipoma (AML) belong to a family of tumors known as perivascular epithelioid cell
tumors (PEComas) that share a common immunophenotypic profile of muscle and …
tumors (PEComas) that share a common immunophenotypic profile of muscle and …
Hamartin, the Product of the Tuberous Sclerosis 1 (TSC1) Gene, Interacts with Tuberin and Appears to Be Localized to Cytoplasmic Vesicles
TL Plank, RS Yeung, EP Henske - Cancer research, 1998 - AACR
Tuberous sclerosis is an inherited syndrome associated with mutations in two tumor suppressor
genes: TSC1 and TSC2. Tuberin, the product of TSC2, appears to be localized to the …
genes: TSC1 and TSC2. Tuberin, the product of TSC2, appears to be localized to the …
Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.
RS Yeung, GH Xiao, F Jin, WC Lee… - Proceedings of the …, 1994 - National Acad Sciences
Genetic predisposition to neoplasia often involves tumor suppressor genes. One such
model of hereditary renal carcinoma was described in the rat by Eker. These tumors share …
model of hereditary renal carcinoma was described in the rat by Eker. These tumors share …