Mice lacking histidine decarboxylase exhibit abnormal mast cells
…, N Hirasawa, E Sakurai, E Buzás, P Kovács… - FEBS …, 2001 - Wiley Online Library
Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate
the role of histamine, we generated HDC‐deficient mice using a gene targeting method. …
the role of histamine, we generated HDC‐deficient mice using a gene targeting method. …
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
…, M Kivimaki, B Knight, S Koskinen, P Kovacs… - Nature …, 2010 - nature.com
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
…, M Koiranen, I Kolcic, S Koskinen, P Kovacs… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
Variation in FTO contributes to childhood obesity and severe adult obesity
…, S Hercberg, C Le Stunff, P Bougnères, P Kovacs… - Nature …, 2007 - nature.com
We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated)
gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and …
gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and …
Genetics and epigenetics in obesity
…, M Keller, L la Cour Poulsen, M Blüher, P Kovacs… - Metabolism, 2019 - Elsevier
Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait. …
markedly increased over the last decades. Obesity maybe considered a heritable trait. …
[HTML][HTML] Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Brown adipose tissue (BAT) dissipates energy 1 , 2 and promotes cardiometabolic health 3 .
Loss of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity …
Loss of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity …
Large-scale migration into Britain during the Middle to Late Bronze Age
Present-day people from England and Wales have more ancestry derived from early European
farmers (EEF) than did people of the Early Bronze Age 1. To understand this, here we …
farmers (EEF) than did people of the Early Bronze Age 1. To understand this, here we …
LEMON–an open source C++ graph template library
This paper introduces LEMON, a generic open source C++ library providing easy-to-use and
efficient implementations of graph and network algorithms and related data structures. The …
efficient implementations of graph and network algorithms and related data structures. The …
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…
on the transcriptome. To investigate the genetics of gene expression, we performed cis…
Decentralized signal control for urban road networks
We propose in this paper a decentralized traffic signal control policy for urban road networks.
Our policy is an adaptation of a so-called BackPressure scheme which has been widely …
Our policy is an adaptation of a so-called BackPressure scheme which has been widely …