User profiles for Peter J. H. Scott

Peter JH Scott

University of Michigan
Verified email at umich.edu
Cited by 6401

Copper-mediated late-stage radiofluorination: five years of impact on preclinical and clinical PET imaging

…, N Wiesner, AF Brooks, MS Sanford, PJH Scott - Clinical and translational …, 2020 - Springer
Purpose Copper-mediated radiofluorination (CMRF) is emerging as the method of choice
for the formation of aromatic C– 18 F bonds. This minireview examines proof-of-concept, …

Radiosyntheses using fluorine-18: the art and science of late stage fluorination

…, R Littich, R Hoareau, P JH Scott - Current topics in …, 2014 - ingentaconnect.com
Positron (β+) emission tomography (PET) is a powerful, noninvasive tool for the in vivo, three-dimensional
imaging of physiological structures and biochemical pathways. The continued …

Iridium‐Catalysed C− H Borylation of Heteroarenes: Balancing Steric and Electronic Regiocontrol

JS Wright, PJH Scott, PG Steel - … Chemie International Edition, 2021 - Wiley Online Library
The iridium‐catalysed borylation of aromatic C−H bonds has become the preferred method
for the synthesis of aromatic organoboron compounds. The reaction is highly efficient, …

Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF

…, AF Brooks, AV Mossine, MS Sanford, PJH Scott - Organic …, 2016 - ACS Publications
A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [ 18 F]KF
is described. This method is fast, uses commercially available reagents, and is compatible …

Late-stage [18 F] fluorination: new solutions to old problems

…, JJ Topczewski, N Ichiishi, MS Sanford, PJH Scott - Chemical …, 2014 - pubs.rsc.org
The last 2–3 years have seen numerous relationships develop between organometallic
chemists, fluorine chemists and PET Centers around the world. These collaborations have led to …

Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids

…, JM Miller, N Ichiishi, MS Sanford, PJH Scott - Organic …, 2015 - ACS Publications
A copper-mediated radiofluorination of aryl- and vinylboronic acids with K 18 F is described.
This method exhibits high functional group tolerance and is effective for the radiofluorination …

Cu-Mediated C–H 18F-Fluorination of Electron-Rich (Hetero)arenes

…, S Thompson, AF Brooks, SW Krska, PJH Scott… - Organic …, 2017 - ACS Publications
This communication describes a method for the nucleophilic radiofluorination of electron-rich
arenes. The reaction involves the initial C(sp 2 )–H functionalization of an electron-rich …

Copper-Catalyzed [18F]Fluorination of (Mesityl)(aryl)iodonium Salts

…, ME Rodnick, MS Sanford, PJH Scott - Organic …, 2014 - ACS Publications
A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium
salts is described. This protocol utilizes [ 18 F]KF to access 18 F-labeled electron-…

Gait speed in Parkinson disease correlates with cholinergic degeneration

…, S Studenski, V Kotagal, RA Koeppe, PJH Scott… - Neurology, 2013 - AAN Enterprises
Objective: We investigated dopaminergic and cholinergic correlates of gait speed in Parkinson
disease (PD) and non-PD control subjects to test the hypothesis that gait dysfunction in …

Synthesis of 68Ga-radiopharmaceuticals using both generator-derived and cyclotron-produced 68Ga as exemplified by [68Ga]Ga-PSMA-11 for prostate cancer PET …

…, MR Piert, MJ Fulham, S Eberl, K Gagnon, PJH Scott - Nature …, 2022 - nature.com
[ 68 Ga]Ga-PSMA-11, a urea-based peptidomimetic, is a diagnostic radiopharmaceutical for
positron emission tomography (PET) imaging that targets the prostate-specific membrane …