User profiles for Paul L. U

Paul Lu

Professor of Computing Science, University of Alberta
Verified email at ualberta.ca
Cited by 4510

Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury

P Lu, LL Jones, EY Snyder, MH Tuszynski - Experimental neurology, 2003 - Elsevier
Neural stem cells (NSCs) offer the potential to replace lost tissue after nervous system injury.
This study investigated whether grafts of NSCs (mouse clone C17.2) could also specifically …

[HTML][HTML] Long-distance growth and connectivity of neural stem cells after severe spinal cord injury

P Lu, Y Wang, L Graham, K McHale, M Gao, D Wu… - Cell, 2012 - cell.com
Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing
growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells …

Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact?

P Lu, A Blesch, MH Tuszynski - Journal of neuroscience …, 2004 - Wiley Online Library
Differentiation of stem cells toward a neuronal lineage normally involves a gradually progressive
restriction in developmental potential and is regulated by a diverse set of specific and …

Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration

…, P Lu, K Nguyen, C Lee-Kubli, H Kumamaru, L Yao… - Nature medicine, 2016 - nature.com
The corticospinal tract (CST) is the most important motor system in humans, yet robust
regeneration of this projection after spinal cord injury (SCI) has not been accomplished. In murine …

Restorative effects of human neural stem cell grafts on the primate spinal cord

ES Rosenzweig, JH Brock, P Lu, H Kumamaru… - Nature medicine, 2018 - nature.com
We grafted human spinal cord–derived neural progenitor cells (NPCs) into sites of cervical
spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression…

Checkers is solved

…, Y Bjornsson, A Kishimoto, M Muller, R Lake, P Lu… - science, 2007 - science.org
The game of checkers has roughly 500 billion billion possible positions (5 × 10 20 ). The task
of solving the game, determining the final result in a game with no mistakes made by either …

Biomimetic 3D-printed scaffolds for spinal cord injury repair

…, O Platoshyn, JN Dulin, J Brock, L Graham, P Lu… - Nature medicine, 2019 - nature.com
Current methods for bioprinting functional tissue lack appropriate biofabrication techniques
to build complex 3D microarchitectures essential for guiding cell growth and promoting tissue …

Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury

P Lu, H Yang, LL Jones, MT Filbin… - Journal of …, 2004 - Soc Neuroscience
Previous attempts to promote regeneration after spinal cord injury have succeeded in stimulating
axonal growth into or around lesion sites but rarely beyond them. We tested whether a …

Predicting subcellular localization of proteins using machine-learned classifiers

Z Lu, D Szafron, R Greiner, P Lu, DS Wishart… - …, 2004 - academic.oup.com
… This paper describes a novel classification technique for predicting subcellular localization
(Lu, 2003). This technique is used in our publicly available web-based Proteome Analyst (PA)…

BASys: a web server for automated bacterial genome annotation

…, JA Cruz, AC Guo, X Dong, P Lu… - Nucleic acids …, 2005 - academic.oup.com
BASys (Bacterial Annotation System) is a web server that supports automated, in-depth
annotation of bacterial genomic (chromosomal and plasmid) sequences. It accepts raw DNA …