The clinical usefulness of brain machine interfaces that employ penetrating silicon microelectrode
arrays is limited by inconsistent performance at chronic time points. While it is widely …

Blood-brain barrier penetration of leucine-enkephalin, methionine-enkephalin, and other
peptide- like compounds was measured after intracarotid injection of three isotopes and was …

The development of new diagnostic/therapeutic modalities for cancer requires a specific
understanding of how tumors differ from normal tissues. Though the key components involved in …

A new method of determining the rate of glucose utilization in brain regions of individual rats
has been used to measure the dose dependency of the reduction of the metabolic activity of …

The kinetics of transport across the blood‐brain barrier and metabolism in brain (hemisphere)
of [ 14 C]2‐fluoro‐2‐deoxy‐d‐glucose (FDG) were compared to that of [ 3 H]2‐deoxy‐d‐…

Recent studies indicate the lumped constant (LC), which defines the relative rates of brain
utilization of glucose and 2‐deoxyglucose (2‐DG), doubles to values > 1.0 under conditions of …

Recent data have generated some interest in technetium-99m-(99mTc) glucaric acid as an
in vivo viability marker. We studied 99mTc-glucaric acid retention in canine models of …

The relative cerebral cortical metabolism of glucose (GLU) and 2‐deoxy‐D‐glucose (DG)
was measured in vivo in control and insulin‐treated hypoglycemic rats. The ratio of the …

An understanding of the mechanisms by which the neuropeptides enter the brain from
blood is important for at least two reasons. Firstly, many, if not all, of the neuropeptides are …

Tryptophol (3-indole ethanol) is a compound which induces sleep, and is formed: (a) in the
liver after disulfiram treatment, and (b) by the parasite in trypanosomal sleeping sickness. We …