Assessment of 18F-PI-2620 as a biomarker in progressive supranuclear palsy
…, A Schildan, M Patt, B Neumaier, O Barret… - JAMA …, 2020 - jamanetwork.com
Importance Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy. Region-specific
tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future …
tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future …
Tau PET imaging with 18F-PI-2620 in patients with Alzheimer disease and healthy controls: a first-in-humans study
A Mueller, S Bullich, O Barret, J Madonia… - Journal of Nuclear …, 2020 - Soc Nuclear Med
18 F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic
feature of Alzheimer disease (AD) and other neurodegenerative disorders. Preclinically, 18 F-…
feature of Alzheimer disease (AD) and other neurodegenerative disorders. Preclinically, 18 F-…
Increased microglial activation in patients with Parkinson disease using [18F]-DPA714 TSPO PET imaging
…, B Kuhnast, MA Peyronneau, O Barret… - Parkinsonism & related …, 2021 - Elsevier
Introduction Increasing evidence suggests that neuroinflammation is active in Parkinson
disease (PD) and contributes to neurodegeneration. This process can be studied in vivo with …
disease (PD) and contributes to neurodegeneration. This process can be studied in vivo with …
Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes
Several studies have demonstrated that intrastriatal injections of fibrillar α-synuclein in
rodent brain induced a Parkinson’s disease-like propagation of Lewy body pathology with …
rodent brain induced a Parkinson’s disease-like propagation of Lewy body pathology with …
[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer's disease
…, A Ogasawara, JN Tinianow, HS Gill, O Barret… - European journal of …, 2019 - Springer
Objective Neurofibrillary tangles (NFTs), consisting of intracellular aggregates of the tau
protein, are a pathological hallmark of Alzheimer’s disease (AD). Here we report the …
protein, are a pathological hallmark of Alzheimer’s disease (AD). Here we report the …
[HTML][HTML] Brain microglia activation and peripheral adaptive immunity in Parkinson's disease: a multimodal PET study
…, TB Song, XL Liu, YX Yao, CS Zhao, O Barret… - Journal of …, 2022 - Springer
Background Abnormal activation of immune system is an important pathogenesis of
Parkinson’s disease, but the relationship between peripheral inflammation, central microglia …
Parkinson’s disease, but the relationship between peripheral inflammation, central microglia …
The phosphodiesterase 10 positron emission tomography tracer,[18F] MNI-659, as a novel biomarker for early Huntington disease
DS Russell, O Barret, DL Jennings, JH Friedman… - JAMA …, 2014 - jamanetwork.com
Importance In Huntington disease (HD) striatal neuron loss precedes and predicts motor
signs or symptoms. Current imaging biomarkers lack adequate sensitivity for assessing the …
signs or symptoms. Current imaging biomarkers lack adequate sensitivity for assessing the …
An adaptive filter for suppression of cardiac and respiratory noise in MRI time series data
RHR Deckers, P van Gelderen, M Ries, O Barret… - Neuroimage, 2006 - Elsevier
The quality of MRI time series data, which allows the study of dynamic processes, is often
affected by confounding sources of signal fluctuation, including the cardiac and respiratory …
affected by confounding sources of signal fluctuation, including the cardiac and respiratory …
Kinetic modeling of the tau PET tracer 18F-AV-1451 in human healthy volunteers and Alzheimer disease subjects
O Barret, D Alagille, S Sanabria… - Journal of Nuclear …, 2017 - Soc Nuclear Med
18 F-AV-1451 is currently the most widely used of several experimental tau PET tracers. The
objective of this study was to evaluate 18 F-AV-1451 binding with full kinetic analysis using …
objective of this study was to evaluate 18 F-AV-1451 binding with full kinetic analysis using …
Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET
…, M Patt, B Neumaier, O Barret… - Journal of cerebral …, 2021 - journals.sagepub.com
The novel tau-PET tracer [ 18 F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s
disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive …
disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive …