Although currently less efficient than their viral counter-parts, nonviral vectors are under intense
investigation as a safer alternative for gene therapy. For successful delivery, the nonviral …

A new family of mesoporous reactive inorganic solids as obtained as aggregates of
nanocrystalline oxides have proven to be effective destructive sorbents for toxic chemicals. In this …

Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified
peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with …

PEGylated glycoproteins (PGPs) were synthesized by copolymerizing a Cys-terminated PEG−peptide,
glycopeptide, and melittin peptide. Compositionally unique PGPs were prepared …

Radionuclide chelators (DOTA, NOTA) functionalized with a monofluorocyclooctyne group
were prepared. These materials reacted rapidly and in high yield with a fully deprotected …

Cyclization techniques are used often to impart higher in vivo stability and binding affinity to
peptide targeting vectors for molecular imaging and therapy. The two most often used …

Untransformed CD4+ Th1 cells stimulated with Ag and APC demonstrated a dependence
on B7-and CD28-mediated costimulatory signals for the expression and function of AP-1 …

Simple Summary Until recently, radiopharmaceuticals have been underutilized for the
curative or the palliative treatment of cancer. Advances in a development program with …

Proteasomes are multisubunit enzymes responsible for the degradation of many cytosolic
proteins. The inhibition of the proteasome has been the subject of intense interest in the …

The 2018 Food and Drug Administration approval of 177 Lu-DOTATATE for the treatment of
somatostatin receptor–positive neuroendocrine tumors (NETs) represents a paradigm-…