In Alzheimer's disease (AD), loss of cortical and hippocampal choline acetyltransferase (ChAT)
activity has been correlated with dementia severity and disease duration, and it forms the …

The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds
with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ) peptide in vitro. The in …

Objective To examine region‐ and substrate‐specific autoradiographic and in vitro binding
patterns of positron emission tomography tracer [F‐18]‐AV‐1451 (previously known as T807)…

An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …

Traumatic brain injury (TBI) is a risk factor for the development of Alzheimer's disease (AD).
This immunohistochemical study determined the extent of AD-related changes in temporal …

During the development of in vivo amyloid imaging agents, an effort was made to use micro-positron
emission tomography (PET) imaging in the presenilin-1 (PS1)/amyloid precursor …

The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-β
protein is an initiating event in Alzheimer's disease (AD). Using amyloid imaging technology…

1295 with alterations in many physiological processes. Altered proteostasis is among the
most obvious, because proteopathy is often evident at the histopathological level. Here, the …

Clinico-pathological correlation studies and positron emission tomography amyloid imaging
studies have shown that some individuals can tolerate substantial amounts of Alzheimer’s …

The human cholinergic basal forebrain (CBF) is comprised of magnocellular hyperchromic
neurons within the septal/diagonal band complex and nucleus basalis (NB) of Meynert. CBF …