[PDF][PDF] Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT

…, T Kunihiro, S Nakano, M Takasaki - Journal of nuclear …, 2000 - Soc Nuclear Med
The aim of this SPECT study was to determine the initial abnormality and longitudinal changes
in regional cerebral blood flow (rCBF) in early Alzheimer's disease (AD) using statistical …

Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals

…, N Yahata, K Ando, K Toyama, A Hoshika, M Takasaki… - Human genetics, 1998 - Springer
The telomerase activity and length of telomeres of peripheral blood mononuclear cells obtained
from 124 healthy individuals aged 4–95years was measured. Telomerase activity level …

Aspiration and infection in the elderly: epidemiology, diagnosis and management

M Kikawada, T Iwamoto, M Takasaki - Drugs & aging, 2005 - Springer
Aspiration of the oropharyngeal or gastric contents by elderly persons often leads to lower
respiratory tract infections, such as aspiration pneumonia or pneumonitis. The existence of …

Diffusion-weighted MR imaging of the hippocampus and temporal white matter in Alzheimer's disease

H Hanyu, H Sakurai, T Iwamoto, M Takasaki… - Journal of the …, 1998 - Elsevier
We investigated the changes in water diffusion in the hippocampus and the temporal white
matter (the temporal stem) in eight patients with possible Alzheimer's disease (AD), 10 …

A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations

…, N Fujikawa, T Date, M Takasaki… - Blood, The Journal …, 2018 - ashpublications.org
An activating mutation of Fms-like tyrosine kinase 3 (FLT3) is the most frequent genetic alteration
associated with poor prognosis in acute myeloid leukemia (AML). Although many FLT3 …

14-3-3 proteins and zeta isoform containing neurofibrillary tangles in patients with Alzheimer's disease

…, A Nakamura, T Iwamoto, K Ikeda, M Takasaki - Acta …, 2004 - Springer
Immunolocalization of 14-3-3 proteins in Alzheimer’s disease (AD) brains was investigated
using isoform-specific antibodies. Weak granular immunoreactivity of 14-3-3 proteins was …

MR analysis of the substantia innominata in normal aging, Alzheimer disease, and other types of dementia

…, H Sakurai, Y Tanaka, M Takasaki… - American Journal …, 2002 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The substantia innominata can be visualized on coronal
thin-section T2-weighted MR images. The purpose of this study was to investigate the …

Platelet activation in the cerebral circulation in different subtypes of ischemic stroke and Binswanger's disease

T Iwamoto, H Kubo, M Takasaki - Stroke, 1995 - Am Heart Assoc
Background and Purpose The sites of platelet activation in ischemic stroke are still unclear
because previous reports have not identified them and various factors accompanied by stroke …

Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer's disease

…, H Sakurai, Y Imon, T Iwamoto, M Takasaki… - Journal of the …, 1999 - Elsevier
We investigated structural changes of the corpus callosum in patients with Alzheimer’s
disease (AD) using sagittal diffusion-weighted (DW) and magnetization transfer (MT) imaging. …

Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease

…, H Matsuda, M Uno, M Takasaki - Journal of Nuclear …, 2001 - Soc Nuclear Med
The aim of this SPECT study was to investigate the effects of donepezil on regional cerebral
blood flow (rCBF) in patients with mild to moderate Alzheimer’s disease (AD) using …