Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START …
…, A Fukao, I Tsuji, T Yamaguchi, Y Ohashi, M Fukuda… - The Lancet, 2016 - thelancet.com
Background Mammography is the only proven method for breast cancer screening that
reduces mortality, although it is inaccurate in young women or women with dense breasts. We …
reduces mortality, although it is inaccurate in young women or women with dense breasts. We …
[HTML][HTML] The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
R Hashizume, M Fukuda, I Maeda, H Nishikawa… - Journal of Biological …, 2001 - ASBMB
BRCA1-BARD1 constitutes a heterodimeric RING finger complex associated through its N-terminal
regions. Here we demonstrate that the BRCA1-BARD1 heterodimeric RING finger …
regions. Here we demonstrate that the BRCA1-BARD1 heterodimeric RING finger …
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex
…, K Miyamoto, D Fox III, M Fukuda… - Proceedings of the …, 2003 - National Acad Sciences
BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1
to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an …
to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an …
[HTML][HTML] Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase
…, K Arima, J Okamoto, RE Klevit, M Fukuda… - Journal of Biological …, 2004 - ASBMB
The breast and ovarian cancer suppressor BRCA1 acquires significant ubiquitin ligase
activity when bound to BARD1 as a RING heterodimer. Although the activity may well be …
activity when bound to BARD1 as a RING heterodimer. Although the activity may well be …
Clinicopathologic characteristics and prognosis of breast cancer patients associated with pregnancy and lactation: analysis of case‐control study in Japan
…, T Fukutomi, T Hirota, M Fukuda… - Japanese journal of …, 1992 - Wiley Online Library
Clinicopathologic characteristics and prognosis of breast cancer patients associated with
pregnancy and lactation were clarified by means of a case‐control study of matched non‐…
pregnancy and lactation were clarified by means of a case‐control study of matched non‐…
BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
…, W Wu, A Koike, R Kojima, H Gomi, M Fukuda… - Cancer research, 2009 - AACR
The breast and ovarian tumor suppressor BRCA1 constitutes a RING heterodimer E3 ligase
with BARD1. BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase …
with BARD1. BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase …
Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum
M Fukuda, NA Peppas, JW McGinity - International journal of pharmaceutics, 2006 - Elsevier
The aim of this study was to investigate the influence of pH, buffer species and ionic
strength on the release mechanism of chlorpheniramine maleate (CPM) from matrix tablets …
strength on the release mechanism of chlorpheniramine maleate (CPM) from matrix tablets …
Floating hot-melt extruded tablets for gastroretentive controlled drug release system
M Fukuda, NA Peppas, JW McGinity - Journal of controlled release, 2006 - Elsevier
The purpose of this study was to investigate the influence of sodium bicarbonate on the
physicochemical properties of controlled release hot-melt extruded (HME) tablets containing …
physicochemical properties of controlled release hot-melt extruded (HME) tablets containing …
Involvement of kinesin family member 2C/mitotic centromere‐associated kinesin overexpression in mammary carcinogenesis
To elucidate the molecular mechanisms of mammary carcinogenesis and discover novel
therapeutic targets for breast cancer, we previously carried out genome‐wide expression …
therapeutic targets for breast cancer, we previously carried out genome‐wide expression …
Ubiquitin and breast cancer
T Ohta, M Fukuda - Oncogene, 2004 - nature.com
The regulation of protein stability by the ubiquitin–proteasome pathway is a critical issue
central to the comprehension of the molecular basis of carcinogenesis. However, ubiquitin …
central to the comprehension of the molecular basis of carcinogenesis. However, ubiquitin …