Associations between the uptake of 111In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) in athymic mice bearing subcutaneous human …
K McLarty, B Cornelissen, DA Scollard, SJ Done… - European journal of …, 2009 - Springer
Purpose The purpose of the study was to investigate the associations between uptake of 111
In-DTPA-trastuzumab, tumour HER2 density and response to trastuzumab (Herceptin) of …
In-DTPA-trastuzumab, tumour HER2 density and response to trastuzumab (Herceptin) of …
Antitumor effects and normal-tissue toxicity of 111In-nuclear localization sequence-trastuzumab in athymic mice bearing HER-positive human breast cancer …
DL Costantini, K McLarty, H Lee, SJ Done… - Journal of Nuclear …, 2010 - Soc Nuclear Med
111 In-nuclear localization sequence-trastuzumab is a radioimmunotherapeutic agent consisting
of trastuzumab modified with NLS peptides (CGYGPKKKRKVGG) and labeled with the …
of trastuzumab modified with NLS peptides (CGYGPKKKRKVGG) and labeled with the …
Trastuzumab-resistant breast cancer cells remain sensitive to the auger electron–emitting radiotherapeutic agent 111In-NLS-trastuzumab and are radiosensitized by …
DL Costantini, K Bateman, K McLarty… - Journal of Nuclear …, 2008 - Soc Nuclear Med
Our goals in this study were to determine whether 111 In-trastuzumab coupled to peptides
harboring nuclear localizing sequences (NLSs) could kill trastuzumab-resistant breast cancer …
harboring nuclear localizing sequences (NLSs) could kill trastuzumab-resistant breast cancer …
Micro-SPECT/CT with 111In-DTPA-pertuzumab sensitively detects trastuzumab-mediated HER2 downregulation and tumor response in athymic mice bearing MDA …
K McLarty, B Cornelissen, Z Cai… - Journal of Nuclear …, 2009 - Soc Nuclear Med
… McLarty K, Reilly R. Molecular imaging as a tool for targeted and personalized cancer …
McLarty K, Cornelissen B, Scollard D, Done S, Chun K, Reilly R. Associations between the uptake …
McLarty K, Cornelissen B, Scollard D, Done S, Chun K, Reilly R. Associations between the uptake …
Cellular penetration and nuclear importation properties of 111In-labeled and 123I-labeled HIV-1 tat peptide immunoconjugates in BT-474 human breast cancer cells
B Cornelissen, M Hu, K McLarty, D Costantini… - Nuclear medicine and …, 2007 - Elsevier
INTRODUCTION: Our objective was to compare the cell penetration and nuclear importation
properties of 111 In-labeled and 123 I-labeled immunoconjugates (ICs) composed of 16-…
properties of 111 In-labeled and 123 I-labeled immunoconjugates (ICs) composed of 16-…
The level of insulin growth factor-1 receptor expression is directly correlated with the tumor uptake of 111In-IGF-1 (E3R) in vivo and the clonogenic survival of breast …
B Cornelissen, K McLarty, V Kersemans… - Nuclear medicine and …, 2008 - Elsevier
INTRODUCTION: Our objective was to define the relationships between tumor uptake of [ 111
In]-IGF-1 and [ 111 In]-IGF-1(E3R), an analogue which does not bind insulin growth factor-…
In]-IGF-1 and [ 111 In]-IGF-1(E3R), an analogue which does not bind insulin growth factor-…
[HTML][HTML] A comparison of 111In- or 64Cu-DOTA-trastuzumab Fab fragments for imaging subcutaneous HER2-positive tumor xenografts in athymic mice using …
C Chan, DA Scollard, K McLarty, S Smith, RM Reilly - EJNMMI research, 2011 - Springer
Background Our objective was to compare 111 In- or 64 Cu-DOTA-trastuzumab Fab fragments
for imaging small or large sc tumor xenografts in athymic mice that display a wide range …
for imaging small or large sc tumor xenografts in athymic mice that display a wide range …
18F-FDG small-animal PET/CT differentiates trastuzumab-responsive from unresponsive human breast cancer xenografts in athymic mice
K McLarty, A Fasih, DA Scollard, SJ Done… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Breast cancers (BCs) with high human epidermal growth factor receptor type 2 (HER2)
expression are most likely to respond to trastuzumab; however, the mechanisms of action of …
expression are most likely to respond to trastuzumab; however, the mechanisms of action of …
Positron-Emission Tomography Imaging of the TSPO with [18F]FEPPA in a Preclinical Breast Cancer Model
N Vasdev, DE Green, DC Vines, K McLarty… - Cancer Biotherapy …, 2013 - liebertpub.com
The present study aims to image the 18-kDa translocator protein (TSPO; formerly known as
the peripheral benzodiazepine receptor) in a preclinical human breast cancer (BC) xenograft …
the peripheral benzodiazepine receptor) in a preclinical human breast cancer (BC) xenograft …
Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice
K McLarty, MD Moran, DA Scollard, C Chan… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: The aim of the study was to evaluate the uptake of [ 18 F]-1-deoxy-1-fluoro-scyllo-inositol
([ 18 F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, …
([ 18 F]-scyllo-inositol) in human breast cancer (BC) and glioma xenografts, …