User profiles for Kaleeckal G. Harikumar
 | Kaleeckal G. Harikumar, Mphil, PhDMayo clinic: Assistant Professor in Medicine Verified email at mayo.edu Cited by 2934 |
Single-molecule FRET imaging of GPCR dimers in living cells
…, A Govindaraju, Z Zhou, KG Harikumar… - Nature …, 2021 - nature.com
Class CG protein-coupled receptors (GPCRs) are known to form stable homodimers or
heterodimers critical for function, but the oligomeric status of class A and B receptors, which …
heterodimers critical for function, but the oligomeric status of class A and B receptors, which …
Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex
Norrin is a cysteine-rich growth factor that is required for angiogenesis in the eye, ear, brain,
and female reproductive organs. It functions as an atypical Wnt ligand by specifically …
and female reproductive organs. It functions as an atypical Wnt ligand by specifically …
Structure of an AMPK complex in an inactive, ATP-bound state
Adenosine monophosphate (AMP)–activated protein kinase (AMPK) regulates metabolism
in response to the cellular energy states. Under energy stress, AMP stabilizes the active …
in response to the cellular energy states. Under energy stress, AMP stabilizes the active …
Crystal structure of the Frizzled 4 receptor in a ligand-free state
…, Y Lu, K Suino-Powell, S Dong, KG Harikumar… - Nature, 2018 - nature.com
Frizzled receptors (FZDs) are class-F G-protein-coupled receptors (GPCRs) that function in
Wnt signalling and are essential for developing and adult organisms 1 , 2 . As central …
Wnt signalling and are essential for developing and adult organisms 1 , 2 . As central …
[HTML][HTML] Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
G protein–coupled receptors (GPCRs) are critical regulators of cellular function acting via
heterotrimeric G proteins as their primary transducers with individual GPCRs capable of …
heterotrimeric G proteins as their primary transducers with individual GPCRs capable of …
[HTML][HTML] Structure and dynamics of the active Gs-coupled human secretin receptor
…, M Khoshouei, MJ Belousoff, KG Harikumar… - Nature …, 2020 - nature.com
The class B secretin GPCR (SecR) has broad physiological effects, with target potential for
treatment of metabolic and cardiovascular disease. Molecular understanding of SecR binding …
treatment of metabolic and cardiovascular disease. Molecular understanding of SecR binding …
[HTML][HTML] Transmembrane segment IV contributes a functionally important interface for oligomerization of the Class II G protein-coupled secretin receptor
KG Harikumar, DI Pinon, LJ Miller - Journal of biological chemistry, 2007 - ASBMB
Oligomerization of the Class II G protein-coupled secretin receptor has been reported, but
the molecular basis for this and its functional significance have not been determined. In the …
the molecular basis for this and its functional significance have not been determined. In the …
Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization
Wnt/β-catenin signaling is activated when extracellular Wnt ligands bind Frizzled (FZD)
receptors at the cell membrane. Wnts bind FZD cysteine-rich domains (CRDs) with high affinity …
receptors at the cell membrane. Wnts bind FZD cysteine-rich domains (CRDs) with high affinity …
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery
KG Harikumar, D Wootten, DI Pinon… - Proceedings of the …, 2012 - National Acad Sciences
The glucagon-like peptide-1 receptor (GLP-1R) is a family BG protein-coupled receptor and
an important drug target for the treatment of type II diabetes, with activation of pancreatic GLP…
an important drug target for the treatment of type II diabetes, with activation of pancreatic GLP…
[HTML][HTML] … effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin …
The lipid microenvironment of receptors can influence their conformation, function, and
regulation. Cholecystokinin (CCK)-stimulated signaling is abnormal in some forms of …
regulation. Cholecystokinin (CCK)-stimulated signaling is abnormal in some forms of …