Resting coronary flow and regional distribution are not affected by narrowing of up to 85
percent of arterial diameter and therefore provide little insight into the effects of stenoses on …

PART I: Coronary flow reserve indicates functional stenosis severity, but may be altered by
physiologic conditions unrelated to stenosis geometry. To assess the effects of changing …

Angiographic severity of coronary artery stenosis has historically been the primary guide to
revascularization or medical management of coronary artery disease. However, physiologic …

Quantitative hemodynamic assessment of coronary stenosis has not been previously
reported. Resting coronary blood flow and its regional distribution are insensitive indexes for …

Background : Fractional flow reserve (FFR) has become an established tool for guiding
treatment, but its graded relationship to clinical outcomes as modulated by medical therapy …

Background Coronary arteries without focal stenosis at angiography are generally considered
non–flow-limiting. However, atherosclerosis is a diffuse process that often remains …

Objective. —To quantify changes in size and severity of myocardial perfusion abnormalities
by positron emission tomography (PET) in patients with coronary artery disease after 5 years …

Occurrence of cerebrovascular accidents has been associated with cocaine abuse. We
investigated the relative distribution of cerebral blood flow (CBF) in groups of chronic cocaine …

Context.—The Lifestyle Heart Trial demonstrated that intensive lifestyle changes may lead to
regression of coronary atherosclerosis after 1 year.Objectives.—To determine the feasibility …

BACKGROUND Severity of coronary artery stenosis has been defined in terms of geometric
dimensions, pressure gradient-flow relations, resistance to flow and coronary flow reserve, …