Covalent modification of histone tails is crucial for transcriptional regulation, mitotic chromosomal
condensation, and heterochromatin formation. Histone H3 lysine 9 (H3-K9) methylation …

Histone H3 Lys 9 (H3-K9) methylation is a crucial epigenetic mark for transcriptional silencing.
G9a is the major mammalian H3-K9 methyltransferase that targets euchromatic regions …

The pluripotency-determining gene Oct3/4 (also called Pou5f1) undergoes postimplantation
silencing in a process mediated by the histone methyltransferase G9a. Microarray analysis …

In serum, mouse embryonic stem cells (mESCs) fluctuate between a naive inner cell mass (ICM)-like
state and a primed epiblast-like state, but when cultured with inhibitors of the …

MATERIALS AND METHODS Plant Materials Vietnamese medicinal plants used in this study
were collected at Seven-Mountain area, Tinh Bien district, Angiang province in March 1998…

The reactivities of various antioxidative compounds including catechol derivatives and
endogenous radical scavengers toward hydroxyl radical ( • OH) were investigated by an electron …

The advancement in epigenetics research over the past several decades has led to the
potential application of epigenome-editing technologies for the treatment of various diseases. In …

Although it is known that OCT4–NANOG are required for maintenance of pluripotent cells in
vitro, the upstream signals that regulate this circuit during early development in vivo have not …

A simple and reproducible rodent glaucoma model is required to elucidate the pathophysiology
of damage to the optic nerve. We developed chronically elevated intraocular pressure (…

Ovulation in the mouse and other mammals is controlled by hormones secreted by the
hypothalamo-pituitary-ovarian axis. We describe anovulation and infertility in female mice lacking …