[HTML][HTML] Characterisation and germline transmission of cultured avian primordial germ cells

J Macdonald, JD Glover, L Taylor, HM Sang… - PloS one, 2010 - journals.plos.org
Background Avian primordial germ cells (PGCs) have significant potential to be used as a
cell-based system for the study and preservation of avian germplasm, and the genetic …

Efficient genetic modification and germ-line transmission of primordial germ cells using piggyBac and Tol2 transposons

J Macdonald, L Taylor, A Sherman… - Proceedings of the …, 2012 - National Acad Sciences
The derivation of germ-line competent avian primordial germ cells establishes a cell-based
model system for the investigation of germ cell differentiation and the production of …

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

S van den Driesche, J Macdonald… - Science translational …, 2015 - science.org
Most common male reproductive disorders are linked to lower testosterone exposure in fetal
life, although the factors responsible for suppressing fetal testosterone remain largely …

Effects of exposure to acetaminophen and ibuprofen on fetal germ cell development in both sexes in rodent and human using multiple experimental systems

…, RA Anderson, J Macdonald… - Environmental …, 2018 - ehp.niehs.nih.gov
Background: Analgesic exposure during pregnancy may affect aspects of fetal gonadal
development that are targeted by endocrine disruptors. Objectives: We investigated whether …

[PDF][PDF] Nodal signaling regulates germ cell development and establishment of seminiferous cords in the human fetal testis

A Jørgensen, J Macdonald, JE Nielsen, KR Kilcoyne… - Cell Reports, 2018 - cell.com
Disruption of human fetal testis development is widely accepted to underlie testicular germ
cell cancer (TGCC) origin and additional disorders within testicular dysgenesis syndrome (…

[HTML][HTML] Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential

RT Mitchell, ME Camacho-Moll, J Macdonald… - Modern Pathology, 2014 - Elsevier
Testicular germ cell cancer develops from premalignant intratubular germ cell neoplasia,
unclassified cells that are believed to arise from failure of normal maturation of fetal germ cells …

Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterization of avian conventional dendritic cells

Z Wu, T Hu, C Chintoan‐Uta, J Macdonald… - …, 2022 - Wiley Online Library
Conventional dendritic cells (cDC) are bone marrow‐derived immune cells that play a central
role in linking innate and adaptive immunity. cDCs efficiently uptake, process and present …

[HTML][HTML] Development and function of chicken XCR1+ conventional dendritic cells

Z Wu, B Shih, J Macdonald, D Meunier… - Frontiers in …, 2023 - frontiersin.org
Conventional dendritic cells (cDCs) are antigen-presenting cells (APCs) that play a central
role in linking innate and adaptive immunity. cDCs have been well described in a number of …

DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads

J Macdonald, KR Kilcoyne, RM Sharpe… - Human …, 2018 - academic.oup.com
STUDY QUESTION Does loss of DMRT1 in human fetal testis alter testicular development
and result in testicular dysgenesis? SUMMARY ANSWER DMRT1 repression in human fetal …

Idiopathic hepatic uptake of 99mTc methylene diphosphonate: a case report

J MacDonald - Journal of Nuclear Medicine Technology, 2001 - Soc Nuclear Med
Objective:Two sequential 99m Tc methylene diphosphonate (MDP) scans were performed
on a 42-y-old woman with insulin-dependent diabetes mellitus, chronic right pyelonephritis …