The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk
for dementia. Hippocampal and medial temporal lobe volumes are larger in higher-fit adults, …

Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many
organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here…

Because children are becoming overweight, unhealthy, and unfit, understanding the
neurocognitive benefits of an active lifestyle in childhood has important public health and …

Research has shown the human brain is organized into separable functional networks
during rest and varied states of cognition, and that aging is associated with specific network …

The ability of killer T cells carrying the CD8 antigen to detect tumours or intracellular pathogens
requires an extensive display of antigenic peptides by major histocompatibility complex (…

Structural variants (SVs) underlie important crop improvement and domestication traits.
However, resolving the extent, diversity, and quantitative impact of SVs has been challenging. …

Efforts to promote the completion of advance directives implicitly assume that completion
rates of these documents, which help ensure care consistent with people’s preferences in the …

The current study examined how a randomized one-year aerobic exercise program for healthy
older adults would affect serum levels of brain-derived neurotrophic factor (BDNF), insulin-…

Background The majority (approximately 75%) of children with cow’s milk allergy tolerate
extensively heated (baked) milk products. Long-term effects of inclusion of dietary baked milk …

Purpose Abiraterone acetate is a prodrug of abiraterone, a selective inhibitor of CYP17, the
enzyme catalyst for two essential steps in androgen biosynthesis. In castration-resistant …