Phase II and pharmacodynamic study of autophagy inhibition using hydroxychloroquine in patients with metastatic pancreatic adenocarcinoma

BM Wolpin, DA Rubinson, X Wang, JA Chan… - The …, 2014 - academic.oup.com
Author Summary Background. Autophagy is a catabolic pathway that permits cells to recycle
intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model …

Analysis of TSC cortical tubers by deep sequencing of TSC1, TSC2 and KRAS demonstrates that small second‐hit mutations in these genes are rare events

W Qin, JA Chan, HV Vinters, GW Mathern… - Brain …, 2010 - Wiley Online Library
Tuberous sclerosis complex (TSC) is an often severe neurocutaneous syndrome. Cortical
tubers are the predominant neuropathological finding in TSC, and their number and location …

Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ

JL Chan, KC Tang, AP Patel, LM Bonilla, N Pierobon… - Blood, 2006 - ashpublications.org
Mesenchymal stem cells (MSCs) are mostly found around the vasculature system of the adult
bone marrow (BM). They function as immune suppressors, express MHC-II, are phagocytic, …

Prospective evaluation of the efficacy of inhaled steroids administered via the AeroDawg spacing chamber in management of dogs with chronic cough

JC Chan, LR Johnson - Journal of veterinary internal medicine, 2023 - Wiley Online Library
Background Glucocorticoids are frequently required for management of cough because of
inflammatory airway disease (IAD) and airway collapse (AWC). Objectives/Hypothesis To …

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

JA Chan, AM Krichevsky, KS Kosik - Cancer research, 2005 - AACR
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression
by targeting the mRNA of protein-coding genes for either cleavage or repression of …

A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes

…, AS Lader, V Walker, JA Chan… - Human molecular …, 2005 - academic.oup.com
Tuberous sclerosis is a hamartoma syndrome due to mutations in TSC1 or TSC2 in which
cardiac rhabdomyomas are seen in ∼60% of patients. These lesions have an unusual natural …

Oligodendroglioma cell lines containing t (1; 19)(q10; p10)

…, MD Blough, ODM Stechishin, JAW Chan… - Neuro …, 2010 - academic.oup.com
Investigating the biology of oligodendroglioma and its characteristic combined deletion of
chromosomal arms 1p and 19q, mediated by an unbalanced translocation, t(1;19)(q10;p10), …

Pathogenesis of Tuberous Sclerosis Subependymal Giant Cell Astrocytomas: Biallelic Inactivation of TSC1 or TSC2 Leads to mTOR Activation

JA Chan, H Zhang, PS Roberts… - … of Neuropathology & …, 2004 - academic.oup.com
In the central nervous system, tuberous sclerosis complex (TSC) is characterized by a range
of lesions including cortical tubers, white matter heterotopias, subependymal nodules, and …

[HTML][HTML] Gene expression in fixed tissues and outcome in hepatocellular carcinoma

…, MJ Wrobel, J Lerner, M Reich, JA Chan… - … England Journal of …, 2008 - Mass Medical Soc
Background It is a challenge to identify patients who, after undergoing potentially curative
treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk …

Inferior auditory time perception in children with motor difficulties

A Chang, YC Li, JF Chan, DG Dotov… - Child …, 2021 - Wiley Online Library
Accurate time perception is crucial for hearing (speech, music) and action (walking, catching).
Motor brain regions are recruited during auditory time perception. Therefore, the …