Phase II and pharmacodynamic study of autophagy inhibition using hydroxychloroquine in patients with metastatic pancreatic adenocarcinoma
BM Wolpin, DA Rubinson, X Wang, JA Chan… - The …, 2014 - academic.oup.com
Author Summary Background. Autophagy is a catabolic pathway that permits cells to recycle
intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model …
intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model …
Analysis of TSC cortical tubers by deep sequencing of TSC1, TSC2 and KRAS demonstrates that small second‐hit mutations in these genes are rare events
Tuberous sclerosis complex (TSC) is an often severe neurocutaneous syndrome. Cortical
tubers are the predominant neuropathological finding in TSC, and their number and location …
tubers are the predominant neuropathological finding in TSC, and their number and location …
Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ
JL Chan, KC Tang, AP Patel, LM Bonilla, N Pierobon… - Blood, 2006 - ashpublications.org
Mesenchymal stem cells (MSCs) are mostly found around the vasculature system of the adult
bone marrow (BM). They function as immune suppressors, express MHC-II, are phagocytic, …
bone marrow (BM). They function as immune suppressors, express MHC-II, are phagocytic, …
Prospective evaluation of the efficacy of inhaled steroids administered via the AeroDawg spacing chamber in management of dogs with chronic cough
JC Chan, LR Johnson - Journal of veterinary internal medicine, 2023 - Wiley Online Library
Background Glucocorticoids are frequently required for management of cough because of
inflammatory airway disease (IAD) and airway collapse (AWC). Objectives/Hypothesis To …
inflammatory airway disease (IAD) and airway collapse (AWC). Objectives/Hypothesis To …
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression
by targeting the mRNA of protein-coding genes for either cleavage or repression of …
by targeting the mRNA of protein-coding genes for either cleavage or repression of …
A mouse model of cardiac rhabdomyoma generated by loss of Tsc1 in ventricular myocytes
…, AS Lader, V Walker, JA Chan… - Human molecular …, 2005 - academic.oup.com
Tuberous sclerosis is a hamartoma syndrome due to mutations in TSC1 or TSC2 in which
cardiac rhabdomyomas are seen in ∼60% of patients. These lesions have an unusual natural …
cardiac rhabdomyomas are seen in ∼60% of patients. These lesions have an unusual natural …
Oligodendroglioma cell lines containing t (1; 19)(q10; p10)
Investigating the biology of oligodendroglioma and its characteristic combined deletion of
chromosomal arms 1p and 19q, mediated by an unbalanced translocation, t(1;19)(q10;p10), …
chromosomal arms 1p and 19q, mediated by an unbalanced translocation, t(1;19)(q10;p10), …
Pathogenesis of Tuberous Sclerosis Subependymal Giant Cell Astrocytomas: Biallelic Inactivation of TSC1 or TSC2 Leads to mTOR Activation
In the central nervous system, tuberous sclerosis complex (TSC) is characterized by a range
of lesions including cortical tubers, white matter heterotopias, subependymal nodules, and …
of lesions including cortical tubers, white matter heterotopias, subependymal nodules, and …
[HTML][HTML] Gene expression in fixed tissues and outcome in hepatocellular carcinoma
…, MJ Wrobel, J Lerner, M Reich, JA Chan… - … England Journal of …, 2008 - Mass Medical Soc
Background It is a challenge to identify patients who, after undergoing potentially curative
treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk …
treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk …
Inferior auditory time perception in children with motor difficulties
Accurate time perception is crucial for hearing (speech, music) and action (walking, catching).
Motor brain regions are recruited during auditory time perception. Therefore, the …
Motor brain regions are recruited during auditory time perception. Therefore, the …