Regulatory T cells (Tregs) limit autoimmunity but also attenuate the magnitude of antipathogen
and antitumor immunity. Understanding the mechanism of Treg function and therapeutic …

Many studies have shown that primary prostate cancers are multifocal 1 , 2 , 3 and are
composed of multiple genetically distinct cancer cell clones 4 , 5 , 6 . Whether or not multiclonal …

Many studies have demonstrated the efficacy of exposure therapy in the treatment of chronic
posttraumatic stress disorder (PTSD). Despite the convincing outcome literature, a concern …

Tissue-derived adenosine, acting via the adenosine A 2A receptor (A 2A R), is emerging as
an important negative regulator of T-cell function. In this report, we demonstrate that A 2A R …

Aberrant DNA methylation patterns may be the earliest somatic genome changes in
prostate cancer. Using real-time methylation-specific PCR, we assessed the extent of …

Background Specific populations of highly tumorigenic cells are thought to exist in many
human tumors, including pancreatic adenocarcinoma. However, the clinical significance of …

T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy.
E3 ligases are involved in maintaining the anergic state. However, the specific molecules …

Although some reports have found an association between increasing HLA disparity between
donor and recipient and fewer relapses after allogeneic blood or marrow transplantation (…

Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome characterized
by anemia, congenital abnormalities, and cancer predisposition. Small ribosomal subunit …

Tumor-initiating cells (TICs) are defined by their ability to form tumors after xenotransplantation
in immunodeficient mice and appear to be relatively rare in most human cancers. Recent …